SFRS14 Inhibitors
SFRS14 inhibitors encompass a diverse array of chemical compounds that, through various mechanisms, can impede the function of the splicing factor SFRS14. These inhibitors target specific cellular processes and interactions that are crucial for the splicing factor's activity. For instance, Isoginkgetin and Madrasin disrupt spliceosome assembly, a fundamental step in the splicing of pre-mRNA, which is the precise stage where SFRS14 is actively involved. By inhibiting spliceosome formation, SFRS14 is prevented from contributing to the splicing process, leading to a decrease in its functional activity. Similarly, Pladienolide B and Meayamycin bind to components of the spliceosome, directly impacting its operation and the function of associated splicing factors like SFRS14. These interactions result in improper splice site recognition and subsequent impediments to the splicing process
Other inhibitors, like Chloroquine and Amiloride, indirectly affect the cellular conditions necessary for efficient mRNA splicing. Chloroquine, by elevating endosomal pH, disrupts endosome-mediated trafficking, which can interfere with the proper localization and function of splicing factors, including SFRS14. This disruption can ultimately lead to a reduction in mRNA splicing efficiency. Amiloride, on the other hand, alters cellular ion balance by blocking the Na^+/H^+ exchange, which can have downstream effects on various cellular processes, including the regulation of intracellular pH and the ionic environment that is essential for the splicing machinery to function optimally. Such an imbalance may impede the activity of splicing factors, such as SFRS14, by altering their conformations or the splicing-related electrochemical gradients, thus indirectly affecting mRNA processing.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
A natural product that inhibits the spliceosome, a complex responsible for splicing pre-mRNA. SFRS14 is a splicing factor, and spliceostatin A inhibits its function by disrupting the assembly and activity of the spliceosome, leading to a reduction in mRNA processing and hence SFRS14 activity. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
A compound that targets the SF3b complex of the spliceosome, leading to the inhibition of splicing and affecting the activity of splicing factors including SFRS14. By binding to the SF3b complex, it interferes with the proper recognition of splice sites, indirectly reducing SFRS14 function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
An antimalarial drug that raises endosomal pH, affecting the endosome-mediated trafficking required for mRNA maturation. This can indirectly inhibit SFRS14 activity by impairing the processing of mRNA transcripts that SFRS14 would normally splice. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
A diuretic that blocks the Na+/H+ exchanger, which can indirectly affect the cellular ionic environment critical for mRNA splicing, thereby potentially inhibiting the function of SFRS14. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $53.00 $104.00 $126.00 $551.00 $1467.00 $2611.00 $11455.00 | 2 | |
A beta-carboline alkaloid that inhibits DYRK1A, a kinase involved in splicing regulation. Inhibition of DYRK1A can lead to alterations in splicing factor activity, thus indirectly impeding SFRS14 function by affecting the splicing machinery. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that changes chromatin structure and can indirectly affect gene expression patterns, including those encoding splicing factors like SFRS14, leading to altered splice factor availability and function. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
A topoisomerase inhibitor that induces DNA damage and can lead to the activation of cellular responses that indirectly modulate splicing factor activity, including SFRS14, due to the DNA damage response potentially affecting mRNA processing. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $57.00 $77.00 | 2 | |
An avermectin that has been shown to alter nuclear transport, which could indirectly affect SFRS14 activity by interfering with the nuclear import and export of splicing factors and their mRNA targets. | ||||||