SET7/9 Antibody (s4E5): sc-56774
- SET7/9 Antibody (s4E5) is a mouse monoclonal IgG2b, cited in 4 publications, provided at 100 µg/ml
- raised against full length SET7/9 of human origin
- recommended for detection of recombinant SET7/9 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SET7/9 Antibody (s4E5). This work is in progress.
SET7/9 Antibody (s4E5) is a mouse monoclonal IgG2b antibody that detects SET7/9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SET7/9, a histone methyltransferase, plays a crucial role in the regulation of gene expression by specifically methylating lysine 4 on histone H3, a modification that is essential for the activation of transcription. This methylation event influences chromatin structure, thereby facilitating the recruitment of transcriptional machinery and other regulatory proteins to gene promoter regions. Anti-SET7/9 antibody (s4E5) enables reliable detection of SET7/9, supporting research into epigenetic regulation and disease mechanisms, as dysregulation of SET7/9 activity can contribute to various diseases, including cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SET7/9 Antibody (s4E5) References:
- SET7/9 mediated methylation of non-histone proteins in mammalian cells. | Pradhan, S., et al. 2009. Epigenetics. 4: 383-7. PMID: 19684477
- SET7/9 interacts and methylates the ribosomal protein, eL42 and regulates protein synthesis. | Mahesh, A., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118611. PMID: 31751593
- KMT Set7/9 is a new regulator of Sam68 STAR-protein. | Vasileva, E., et al. 2020. Biochem Biophys Res Commun. 525: 1018-1024. PMID: 32178870
- Set7/9 controls proliferation and genotoxic drug resistance of NSCLC cells. | Daks, A., et al. 2021. Biochem Biophys Res Commun. 572: 41-48. PMID: 34343833
- Non-histone Methylation of SET7/9 and its Biological Functions. | Gao, L., et al. 2022. Recent Pat Anticancer Drug Discov. 17: 231-243. PMID: 34856916
- The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response. | Daks, A., et al. 2022. Life (Basel). 12: PMID: 35330113
- Methyltransferase Set7/9 as a Multifaceted Regulator of ROS Response. | Daks, A., et al. 2023. Int J Biol Sci. 19: 2304-2318. PMID: 37215983
- SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A. | Gu, R., et al. 2023. JCI Insight. 8: PMID: 37870957
- Set7/9 aggravates ischemic brain injury via enhancing glutamine metabolism in a blocking Sirt5 manner. | Wang, J., et al. 2024. Cell Death Differ. 31: 511-523. PMID: 38365969
- Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development. | Daks, A., et al. 2024. Biol Direct. 19: 41. PMID: 38812048
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SET7/9 Antibody (s4E5) | sc-56774 | 100 µg/ml | $322.00 |