Serglycin Antibody (H-9): sc-393521
- Serglycin Antibody (H-9) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 112-139 near the C-terminus of Serglycin of human origin
- recommended for detection of precursor and mature Serglycin of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Serglycin Antibody (H-9) for WB applications. These reagents are now offered in bundles with Serglycin Antibody (H-9) (see ordering information below).
QUICK LINKS
SEE ALSO...
Serglycin Antibody (H-9) is a mouse monoclonal IgG2b antibody that detects serglycin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Serglycin is a chondroitin sulfate-bearing proteoglycan primarily located in the secretory granules of various hematopoietic cells, where serglycin plays a crucial role in the storage and transport of cationic granular proteins, including granzymes and perforin. This localization is significant because serglycin facilitates the granule-mediated exocytosis pathway, which is essential for the immune system′s ability to eliminate virus-infected and tumor cells through the action of cytotoxic T lymphocytes and natural killer cells. By ensuring the proper transport and release of these cytotoxic proteins, serglycin is vital for maintaining effective immune responses and mediating apoptosis in target cells. Anti-serglycin antibody (H-9) is an invaluable tool for researchers studying immune function and the mechanisms of granule exocytosis, providing insights into the complex interactions that underpin cellular responses to infection and malignancy.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Serglycin Antibody (H-9) References:
- Localization of serglycin in human neutrophil granulocytes and their precursors. | Niemann, CU., et al. 2004. J Leukoc Biol. 76: 406-15. PMID: 15136585
- Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. | Li, XJ., et al. 2011. Cancer Res. 71: 3162-72. PMID: 21289131
- Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization. | Purushothaman, A. and Toole, BP. 2014. J Biol Chem. 289: 5499-509. PMID: 24403068
- Serglycin in Quiescent and Proliferating Primary Endothelial Cells. | Reine, TM., et al. 2015. PLoS One. 10: e0145584. PMID: 26694746
- Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis. | Chu, Q., et al. 2016. Cell Death Dis. 7: e2456. PMID: 27809309
- Tumorigenic functions of serglycin: Regulatory roles in epithelial to mesenchymal transition and oncogenic signaling. | Manou, D., et al. 2020. Semin Cancer Biol. 62: 108-115. PMID: 31279836
- Association between Serum Serglycin Levels and St-Segment Elevation Myocardial Infarction. | Ilgın, BU., et al. 2021. Arq Bras Cardiol. 116: 756-762. PMID: 33886724
- Clinical Significance of Serglycin Expression in Human Breast Cancer Patients. | Hosoya, K., et al. 2022. Anticancer Res. 42: 279-285. PMID: 34969735
- Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration. | Chen, F., et al. 2024. Nat Commun. 15: 47. PMID: 38167807
- Tumour cell-derived serglycin promotes IL-8 secretion of CAFs in gastric cancer. | Li, X., et al. 2024. Br J Cancer. 131: 271-282. PMID: 38862740
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Serglycin Antibody (H-9) | sc-393521 | 200 µg/ml | $316.00 | |||
Serglycin Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-538235 | 200 µg Ab; 10 µg BP | $354.00 | |||
Serglycin Antibody (H-9): m-IgGκ BP-HRP Bundle | sc-535808 | 200 µg Ab; 40 µg BP | $354.00 | |||
Serglycin Antibody (H-9): m-IgG2b BP-HRP Bundle | sc-549929 | 200 µg Ab; 10 µg BP | $354.00 | |||
Serglycin (H-9) Neutralizing Peptide | sc-393521 P | 100 µg/0.5 ml | $68.00 |