SERCA1 Antibody (4i352): sc-73017

SERCA1 Antibody (4i352) is a mouse monoclonal IgG1 antibody that detects SERCA1 in mouse, rat, rabbit, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SERCA1, a member of the sarcoplasmic or endoplasmic reticulum calcium ATPase (SERCA) family, plays a crucial role in muscle physiology by mediating the uptake of calcium ions (Ca2+) into the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. The proper functioning of SERCA1 is vital for maintaining low cytoplasmic calcium concentrations, thereby preventing excessive muscle contraction and ensuring efficient muscle relaxation. This is particularly important in type II (fast) skeletal muscle, where SERCA1 is exclusively expressed, allowing for rapid muscle responses. Dysregulation of SERCA1 can lead to impaired muscle function and has been implicated in various muscle-related diseases. Anti-SERCA1 antibody (4i352) is an invaluable tool for researchers studying calcium homeostasis and muscle physiology, providing insights into the molecular mechanisms underlying muscle contraction and relaxation.

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SERCA1 Antibody (4i352) References:

1. Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis.  |  Chami, M., et al. 2000. Oncogene. 19: 2877-86. PMID: 10871838
2. Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice.  |  Pan, Y., et al. 2003. J Biol Chem. 278: 13367-75. PMID: 12556521
3. RyR1/SERCA1 cross-talk regulation of calcium transport in heavy sarcoplasmic reticulum vesicles.  |  Gilchrist, JS., et al. 2003. Can J Physiol Pharmacol. 81: 220-33. PMID: 12733821
4. Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress.  |  Chami, M., et al. 2008. Mol Cell. 32: 641-51. PMID: 19061639
5. The localization of the ER retrieval sequence for the calcium pump SERCA1.  |  Watson, HR., et al. 2011. Mol Membr Biol. 28: 216-26. PMID: 21457059
6. Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.  |  Zhao, Y., et al. 2015. Biochim Biophys Acta. 1852: 2042-7. PMID: 26170059
7. Sarcolipin (sln) and Sarcoplasmic Reticulum calcium ATPase pump (serca1) expression increase in Japanese medaka (Oryzias latipes) skeletal muscle tissue following cold challenge.  |  Robinson, S., et al. 2024. Comp Biochem Physiol A Mol Integr Physiol. 287: 111534. PMID: 37844835
8. Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease.  |  Odermatt, A., et al. 1997. Genomics. 45: 541-53. PMID: 9367679
9. Structure/function analysis of the Ca2+ binding and translocation domain of SERCA1 and the role in Brody disease of the ATP2A1 gene encoding SERCA1.  |  MacLennan, DH., et al. 1997. Ann N Y Acad Sci. 834: 175-85. PMID: 9405806
10. Cell-specific promoter in adenovirus vector for transgenic expression of SERCA1 ATPase in cardiac myocytes.  |  Inesi, G., et al. 1998. Am J Physiol. 274: C645-53. PMID: 9530095

The preferred SERCA1/2/3 antibody is SERCA1/2/3 Antibody (B-7): sc-271669.