Septin 5 Antibody (SP20): sc-65512

Septin 5 Antibody (SP20) is a mouse monoclonal IgG1 antibody that detects Septin 5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Septin 5 plays a crucial role in cytoskeleton organization and is involved in various cellular processes, including cytokinesis and exocytosis regulation. Septin 5 is primarily found in the cytoplasm and at the midbody during cell division, where Septin 5 contributes to contractile ring formation and final separation of daughter cells. This localization is essential for maintaining proper cell division and ensuring accurate genetic material distribution, which is vital for preventing aneuploidy and other cellular dysfunctions. Additionally, Septin 5 has been implicated in neurodegenerative diseases, as Septin 5 interacts with other proteins involved in neuronal function and integrity. Anti-Septin 5 antibody (SP20) is an invaluable tool for researchers studying these critical processes and the underlying mechanisms of related pathologies.

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Septin 5 Antibody (SP20) References:

1. Expression profiles of proteins in fetal brain with Down syndrome.  |  Cheon, MS., et al. 2001. J Neural Transm Suppl. 311-9. PMID: 11771754
2. Septins regulate developmental switching from microdomain to nanodomain coupling of Ca(2+) influx to neurotransmitter release at a central synapse.  |  Yang, YM., et al. 2010. Neuron. 67: 100-15. PMID: 20624595
3. Proteomic analysis of proteins expressing in regions of rat brain by a combination of SDS-PAGE with nano-liquid chromatography-quadrupole-time of flight tandem mass spectrometry.  |  Katagiri, T., et al. 2010. Proteome Sci. 8: 41. PMID: 20659346
4. Differential expression of synaptic proteins in unilateral 6-OHDA lesioned rat model-A comparative proteomics approach.  |  Xiong, Y., et al. 2014. Proteomics. 14: 1808-19. PMID: 24841483
5. Proteomic investigation of the hippocampus in prenatally stressed mice implicates changes in membrane trafficking, cytoskeletal, and metabolic function.  |  Föcking, M., et al. 2014. Dev Neurosci. 36: 432-42. PMID: 25138076
6. Coexistence of Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibodies in Adult and Pediatric Patients.  |  Kunchok, A., et al. 2020. JAMA Neurol. 77: 257-259. PMID: 31657826
7. Association Between Tumor Necrosis Factor Inhibitor Exposure and Inflammatory Central Nervous System Events.  |  Kunchok, A., et al. 2020. JAMA Neurol. 77: 937-946. PMID: 32421186
8. Diagnostic value of aquaporin-4-IgG live cell based assay in neuromyelitis optica spectrum disorders.  |  Redenbaugh, V., et al. 2021. Mult Scler J Exp Transl Clin. 7: 20552173211052656. PMID: 34868626
9. SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study.  |  Zivelonghi, C., et al. 2023. Immunol Res. 71: 717-724. PMID: 37171542
10. Clinical features and outcomes in primary nervous system histiocytic neoplasms.  |  Nathoo, N., et al. 2024. Blood Cancer J. 14: 101. PMID: 38902249

The preferred Septin 5 antibody is Septin 5 Antibody (SP18): sc-20040.