SENP5 Antibody (3C2): sc-293373
- SENP5 Antibody (3C2) is a mouse monoclonal IgG2b κ SENP5 antibody provided at 100 µg/ml
- raised against amino acids 2-109 of SENP5 of human origin
- recommended for detection of SENP5 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SENP5 Antibody (3C2). This work is in progress.
SENP5 Antibody (3C2) is a mouse monoclonal IgG2b kappa light chain antibody that detects SENP5 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SENP5 (3C2) antibody is available as a non-conjugated format. SENP5, a member of the sentrin-specific protease family, plays a crucial role in regulating SUMO (small ubiquitin-related modifier) pathways, which are essential for various cellular processes, including transcription, DNA repair, and cell cycle regulation. SENP5 is localized in the nucleolus, where SENP5 preferentially processes SUMO-3, a modification vital for proper functioning of numerous target proteins during mitosis and cytokinesis. SENP5′s ability to modulate SUMOylation influences stability and activity of key regulatory proteins, thereby impacting cellular responses to stress and developmental cues. SENP5′s interactions with other proteins, such as HIPK2, highlight SENP5′s importance in cellular signaling pathways, making SENP5 a valuable target for research in cancer and developmental biology. With robust performance in multiple applications, anti-SENP5 antibody (3C2) serves as an essential tool for researchers investigating SUMOylation′s intricate roles in human health and disease.
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SENP5 Antibody (3C2) References:
- Differential regulation of sentrinized proteins by a novel sentrin-specific protease. | Gong, L., et al. 2000. J Biol Chem. 275: 3355-9. PMID: 10652325
- A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. | Kim, KI., et al. 2000. J Biol Chem. 275: 14102-6. PMID: 10799485
- SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. | Cheng, J., et al. 2004. Mol Cell Biol. 24: 6021-8. PMID: 15199155
- A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. | Reverter, D. and Lima, CD. 2004. Structure. 12: 1519-31. PMID: 15296745
- Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. | Xu, Z. and Au, SW. 2005. Biochem J. 386: 325-30. PMID: 15487983
- Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. | Kim, YH., et al. 2005. FEBS Lett. 579: 6272-8. PMID: 16253240
- The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. | Shen, LN., et al. 2006. Biochem J. 397: 279-88. PMID: 16553580
- Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. | Gong, L. and Yeh, ET. 2006. J Biol Chem. 281: 15869-77. PMID: 16608850
- The SUMO-specific protease SENP5 is required for cell division. | Di Bacco, A., et al. 2006. Mol Cell Biol. 26: 4489-98. PMID: 16738315
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SENP5 Antibody (3C2) | sc-293373 | 100 µg/ml | $316.00 |