Selenoprotein S Antibody (D-1): sc-365498
- Selenoprotein S Antibody (D-1) is a mouse monoclonal IgG1 κ Selenoprotein S antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-189 of Selenoprotein S of human origin
- Selenoprotein S Antibody (D-1) is recommended for detection of Selenoprotein S of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Selenoprotein S Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Selenoprotein S Antibody (D-1) for WB applications. This reagent is now offered in a bundle with Selenoprotein S Antibody (D-1) (see ordering information below).
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Selenoprotein S Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Selenoprotein S protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Selenoprotein S (D-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Selenoprotein S, also known as VIMP or SELS, is a critical 189 amino acid single-pass membrane protein located in the endoplasmic reticulum (ER), where Selenoprotein S plays a vital role in maintaining cellular homeostasis. Selenoprotein S contains a selenocysteine residue at its active site, which is essential for function in the degradation of misfolded ER proteins. By interacting with Derlin-1 and valosin-containing protein (VCP), Selenoprotein S facilitates the transfer of these misfolded proteins from the ER to the cytosol, where misfolded proteins are targeted for proteasomal degradation. This process is crucial for preventing the accumulation of dysfunctional proteins that can lead to cellular stress and disease. Aberrant expression of Selenoprotein S has been linked to various pathologies, including diabetes, cardiovascular disease, and rheumatoid arthritis, highlighting Selenoprotein S importance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Selenoprotein S Antibody (D-1) References:
- Characterization of mammalian selenoproteomes. | Kryukov, GV., et al. 2003. Science. 300: 1439-43. PMID: 12775843
- Genetic variation in selenoprotein S influences inflammatory response. | Curran, JE., et al. 2005. Nat Genet. 37: 1234-41. PMID: 16227999
- SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. | Kim, KH., et al. 2007. Biochem Biophys Res Commun. 354: 127-32. PMID: 17210132
- The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation. | Seiderer, J., et al. 2007. Tissue Antigens. 70: 238-46. PMID: 17661913
- Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases. | Martínez, A., et al. 2008. BMC Genomics. 9: 329. PMID: 18625033
- Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells. | Zeng, J., et al. 2008. Arch Biochem Biophys. 478: 1-6. PMID: 18675776
- Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus. | Du, JL., et al. 2008. Chin Med J (Engl). 121: 1165-8. PMID: 18710632
- Evidence of epistasis between interleukin 1 and selenoprotein-S with susceptibility to rheumatoid arthritis. | Marinou, I., et al. 2009. Ann Rheum Dis. 68: 1494-7. PMID: 18728048
- Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism influences the susceptibility to gastric cancer in the Japanese population. | Shibata, T., et al. 2009. BMC Gastroenterol. 9: 2. PMID: 19144102
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Selenoprotein S Antibody (D-1) | sc-365498 | 200 µg/ml | $316.00 | |||
Selenoprotein S Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-525885 | 200 µg Ab; 10 µg BP | $354.00 | |||
Selenoprotein S Antibody (D-1) AC | sc-365498 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Selenoprotein S Antibody (D-1) HRP | sc-365498 HRP | 200 µg/ml | $316.00 | |||
Selenoprotein S Antibody (D-1) FITC | sc-365498 FITC | 200 µg/ml | $330.00 | |||
Selenoprotein S Antibody (D-1) PE | sc-365498 PE | 200 µg/ml | $343.00 | |||
Selenoprotein S Antibody (D-1) Alexa Fluor® 488 | sc-365498 AF488 | 200 µg/ml | $357.00 | |||
Selenoprotein S Antibody (D-1) Alexa Fluor® 546 | sc-365498 AF546 | 200 µg/ml | $357.00 | |||
Selenoprotein S Antibody (D-1) Alexa Fluor® 594 | sc-365498 AF594 | 200 µg/ml | $357.00 | |||
Selenoprotein S Antibody (D-1) Alexa Fluor® 647 | sc-365498 AF647 | 200 µg/ml | $357.00 | |||
Selenoprotein S Antibody (D-1) Alexa Fluor® 680 | sc-365498 AF680 | 200 µg/ml | $357.00 | |||
Selenoprotein S Antibody (D-1) Alexa Fluor® 790 | sc-365498 AF790 | 200 µg/ml | $357.00 |