Selenoprotein P Antibody (B-9): sc-376858

Selenoprotein P Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Selenoprotein P of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Selenoprotein P antibody (B-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Selenoprotein P (SEPP1) plays a crucial role in selenium transport and metabolism, acting as a major extracellular selenoprotein that helps maintain selenium homeostasis in the body. SEPP1 is primarily synthesized in the liver and secreted into the bloodstream, where SEPP1 binds to heparin and interacts with endothelial cells, thereby contributing to antioxidant defense mechanisms in the extracellular space. Notably, Selenoprotein P is unique among selenoproteins due to multiple selenocysteine residues, which are essential for function and stability. SEPP1 is encoded on human chromosome 5q31, and SEPP1 expression is regulated by selenium availability, highlighting this trace element′s importance in human health. Deficiencies in selenium can lead to reduced levels of Selenoprotein P, which has been associated with various pathological conditions, underscoring SEPP1′s significance in cellular protection and overall metabolic processes.

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Selenoprotein P Antibody (B-9) References:

1. Observations on effect of sodium selenite in prevention of Keshan disease.  |  . 1979. Chin Med J (Engl). 92: 471-6. PMID: 114371
2. Molecular mechanism of selenoprotein P synthesis.  |  Shetty, S. and Copeland, PR. 2018. Biochim Biophys Acta Gen Subj. 1862: 2506-2510. PMID: 29656121
3. Selenoprotein P and its potential role in Alzheimer's disease.  |  Solovyev, N. 2020. Hormones (Athens). 19: 73-79. PMID: 31250406
4. Selenoprotein P as an in vivo redox regulator: disorders related to its deficiency and excess.  |  Saito, Y. 2020. J Clin Biochem Nutr. 66: 1-7. PMID: 32001950
5. Hepatokine Selenoprotein P-Mediated Reductive Stress Causes Resistance to Intracellular Signal Transduction.  |  Takamura, T. 2020. Antioxid Redox Signal. 33: 517-524. PMID: 32295394
6. Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat.  |  Oo, SM., et al. 2022. Cell Rep. 38: 110566. PMID: 35354056
7. Selenoprotein P - Selenium transport protein, enzyme and biomarker of selenium status.  |  Schomburg, L. 2022. Free Radic Biol Med. 191: 150-163. PMID: 36067902
8. Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia.  |  Vinceti, M., et al. 2023. Sci Rep. 13: 8792. PMID: 37258587
9. Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P.  |  Schwarz, M., et al. 2023. Nat Commun. 14: 3479. PMID: 37311819
10. Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA.  |  Hill, KE., et al. 1993. Proc Natl Acad Sci U S A. 90: 537-41. PMID: 8421687
11. Multiple forms of selenoprotein P in rat plasma.  |  Chittum, HS., et al. 1996. Arch Biochem Biophys. 325: 124-8. PMID: 8554336
12. Human selenoprotein P gene maps to 5q31.  |  Hill, KE., et al. 1996. Genomics. 36: 550-1. PMID: 8884283

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Selenoprotein P Antibody (B-9) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-Selenoprotein P Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Selenoprotein P Antibody (B-9) Specifications

Alternate Product Name: SEPP1

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 82-381

Epitope Target: Selenoprotein P

Epitope Species: human

Product Reactivity/Detection: Selenoprotein P

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for Selenoprotein P Antibody (B-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin