SELENBP1 Antibody (G-9): sc-373726

SELENBP1 Antibody (G-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects SELENBP1 protein of mouse, rat, and human origin, as well as SELENBP2 of mouse origin, through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-SELENBP1 antibody (G-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SELENBP1, also known as selenium binding protein 1, plays a crucial role in cellular processes by binding selenium, an essential trace element incorporated into selenoproteins as selenocysteine. This binding is vital for proper functioning of various selenoproteins, which are involved in antioxidant defense and thyroid hormone metabolism. SELENBP1 is a 472 amino acid peripheral membrane protein that exists in two alternatively spliced isoforms and is implicated in detecting xenobiotics within the cytoplasm. SELENBP1′s involvement in intra-Golgi protein transport, selenium-dependent cell growth inhibition, and regulation of protein degradation through ubiquitination and deubiquitination processes highlights its importance in maintaining cellular homeostasis. SELENBP1 is highly expressed in tissues such as prostate, lung, kidney, pancreas, and liver, and shows notably upregulated expression in blood and brain of individuals with schizophrenia, suggesting a potential role in neuropsychiatric disorders.

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SELENBP1 Antibody (G-9) References:

1. Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease.  |  Okunuki, Y., et al. 2007. Exp Eye Res. 84: 823-31. PMID: 17343851
2. The utility of SELENBP1 gene expression as a biomarker for major psychotic disorders: replication in schizophrenia and extension to bipolar disorder with psychosis.  |  Kanazawa, T., et al. 2008. Am J Med Genet B Neuropsychiatr Genet. 147B: 686-9. PMID: 18163446
3. Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer.  |  Li, T., et al. 2008. Mol Nutr Food Res. 52: 1289-99. PMID: 18435490
4. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner.  |  Jeong, JY., et al. 2009. Biochem Biophys Res Commun. 379: 583-8. PMID: 19118533
5. Family-based association study of SELENBP1 in schizophrenia.  |  Kanazawa, T., et al. 2009. Schizophr Res. 113: 268-72. PMID: 19596560
6. Progressive loss of selenium-binding protein 1 expression correlates with increasing epithelial proliferation and papillary complexity in ovarian serous borderline tumor and low-grade serous carcinoma.  |  Zhang, C., et al. 2010. Hum Pathol. 41: 255-61. PMID: 19896693
7. Different patterns of regulation of the genes encoding the closely related 56 kDa selenium- and acetaminophen-binding proteins in normal tissues and during carcinogenesis.  |  Lanfear, J., et al. 1993. Carcinogenesis. 14: 335-40. PMID: 8453708
8. Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein.  |  Chang, PW., et al. 1997. J Cell Biochem. 64: 217-24. PMID: 9027582

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SELENBP1 Antibody (G-9) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-SELENBP1 Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SELENBP1 Antibody (G-9) Specifications

Alternate Product Name: SELENBP1

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 401-430

Epitope Target: SELENBP1

Epitope Species: human

Product Reactivity/Detection: SELENBP1 of mouse, rat and human origin, and SELENBP2 of mouse origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for SELENBP1 Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin