SEI-1 Antibody (3H4): sc-517080
- SEI-1 Antibody (3H4) is a mouse monoclonal IgG2a κ SEI-1 antibody provided at 100 µg/ml
- raised against amino acids 1-236 representing full length SEI-1 of human origin
- recommended for detection of SEI-1 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SEI-1 Antibody (3H4). This work is in progress.
SEI-1 Antibody (3H4) is a mouse monoclonal IgG2a kappa light chain antibody that detects SEI-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SEI-1 (3H4) antibody is available as the non-conjugated form. SEI-1 protein, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), plays a crucial role as a transcriptional regulator that integrates signals from various transcription factors. SEI-1 is particularly important for regulating gene expression at E2F-responsive promoters, where SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, facilitating signal transmission to the promoter and enhancing transcriptional activity. SEI-1 forms a multiprotein complex with E2F-1 and DP-1, exhibiting varying expression levels throughout the cell cycle, which allows SEI-1 to effectively regulate cell cycle progression during the G1 and S phases. SEI-1 can also modulate the activity of the cyclin D-Cdk4 complex, making cyclin D-Cdk4 resistant to p16 inhibitory effects, thereby influencing cell cycle dynamics. Overexpression of SEI-1 has been linked to the development of squamous cell carcinomas of the head and neck, highlighting SEI-1′s potential role in cancer biology and making SEI-1 a significant target for research and therapeutic interventions.
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SEI-1 Antibody (3H4) References:
- TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. | Hsu, SI., et al. 2001. EMBO J. 20: 2273-85. PMID: 11331592
- Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines. | Tang, TC., et al. 2002. Cancer Res. 62: 7157-61. PMID: 12499249
- TRIP-Br links E2F to novel functions in the regulation of cyclin E expression during cell cycle progression and in the maintenance of genomic stability. | Sim, KG., et al. 2004. Cell Cycle. 3: 1296-304. PMID: 15467469
- Oncogenic transformation by SEI-1 is associated with chromosomal instability. | Tang, DJ., et al. 2005. Cancer Res. 65: 6504-8. PMID: 16061626
- SEI family of nuclear factors regulates p53-dependent transcriptional activation. | Watanabe-Fukunaga, R., et al. 2005. Genes Cells. 10: 851-60. PMID: 16098148
- Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). | Li, J., et al. 2005. Biochemistry. 44: 13246-56. PMID: 16201750
- p21WAF1/CIP1 gene is inactivated in metastatic prostatic cancer cell lines by promoter methylation. | Bott, SR., et al. 2005. Prostate Cancer Prostatic Dis. 8: 321-6. PMID: 16276353
- The TRIP-Br family of transcriptional regulators is essential for the execution of cyclin E-mediated cell cycle progression. | Sim, KG., et al. 2006. Cell Cycle. 5: 1111-5. PMID: 16721052
- Transcriptional and subcellular regulation of the TRIP-Br family. | Lai, IL., et al. 2007. Gene. 388: 102-9. PMID: 17141982
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SEI-1 Antibody (3H4) | sc-517080 | 100 µg/ml | $322.00 |