SDSL Antibody (B-8): sc-514341
- SDSL Antibody (B-8) is a mouse monoclonal IgG2a κ SDSL antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 11-27 near the N-terminus of SDSL of human origin
- SDSL Antibody (B-8) is recommended for detection of SDSL of human origin by WB, IP, IF and ELISA
- Anti-SDSL Antibody (B-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for SDSL Antibody (B-8) for WB applications. These reagents are now offered in bundles with SDSL Antibody (B-8) (see ordering information below).
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SDSL Antibody (B-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects SDSL protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SDSL (B-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SDSL protein, also known as serine dehydratase-like or serine dehydratase 2, consists of 329 amino acids and is a member of the serine/threonine dehydratase family. SDSL plays a crucial role in protein metabolism, particularly in converting L-serine to pyruvate and ammonia, similar to L-serine dehydratase. SDSL localizes primarily in the cytoplasm, efficiently participating in metabolic pathways essential for maintaining cellular homeostasis and energy production. Proper functioning of SDSL is vital, as dysregulation of serine metabolism can lead to various metabolic disorders and impact overall cellular health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SDSL Antibody (B-8) References:
- Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase. | Xue, HH., et al. 1999. J Biol Chem. 274: 16028-33. PMID: 10347152
- Crystallization and preliminary crystallographic analysis of human serine dehydratase. | Sun, L., et al. 2003. Acta Crystallogr D Biol Crystallogr. 59: 2297-9. PMID: 14646100
- Some biochemical and histochemical properties of human liver serine dehydratase. | Kashii, T., et al. 2005. Int J Biochem Cell Biol. 37: 574-89. PMID: 15618015
- Serine dehydratase expression decreases in rat livers injured by chronic thioacetamide ingestion. | López-Flores, I., et al. 2005. Mol Cell Biochem. 268: 33-43. PMID: 15724435
- SDSL-ESR-based protein structure characterization. | Strancar, J., et al. 2010. Eur Biophys J. 39: 499-511. PMID: 19669752
- Probing structural transitions in both structured and disordered proteins using site-directed spin-labeling EPR spectroscopy. | Longhi, S., et al. 2011. J Pept Sci. 17: 315-28. PMID: 21351321
- Human liver serine dehydratase. cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources. | Ogawa, H., et al. 1989. J Biol Chem. 264: 15818-23. PMID: 2674117
- Effects of Fe2+/Fe3+ Binding to Human Frataxin and Its D122Y Variant, as Revealed by Site-Directed Spin Labeling (SDSL) EPR Complemented by Fluorescence and Circular Dichroism Spectroscopies. | Doni, D., et al. 2020. Int J Mol Sci. 21: PMID: 33348670
- Comprehensive analysis of mitochondrial dysfunction and necroptosis in intracranial aneurysms from the perspective of predictive, preventative, and personalized medicine. | Chen, B., et al. 2023. Apoptosis. 28: 1452-1468. PMID: 37410216
- Identification of cuproptosis-related genes and immune infiltration in dilated cardiomyopathy. | Lin, Y., et al. 2024. Int J Cardiol. 399: 131702. PMID: 38168558
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SDSL Antibody (B-8) | sc-514341 | 200 µg/ml | $316.00 | |||
SDSL Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-526360 | 200 µg Ab; 10 µg BP | $354.00 | |||
SDSL Antibody (B-8): m-IgG2a BP-HRP Bundle | sc-546604 | 200 µg Ab; 10 µg BP | $354.00 | |||
SDSL Antibody (B-8) AC | sc-514341 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SDSL Antibody (B-8) HRP | sc-514341 HRP | 200 µg/ml | $316.00 | |||
SDSL Antibody (B-8) FITC | sc-514341 FITC | 200 µg/ml | $330.00 | |||
SDSL Antibody (B-8) PE | sc-514341 PE | 200 µg/ml | $343.00 | |||
SDSL Antibody (B-8) Alexa Fluor® 488 | sc-514341 AF488 | 200 µg/ml | $357.00 | |||
SDSL Antibody (B-8) Alexa Fluor® 546 | sc-514341 AF546 | 200 µg/ml | $357.00 | |||
SDSL Antibody (B-8) Alexa Fluor® 594 | sc-514341 AF594 | 200 µg/ml | $357.00 | |||
SDSL Antibody (B-8) Alexa Fluor® 647 | sc-514341 AF647 | 200 µg/ml | $357.00 | |||
SDSL Antibody (B-8) Alexa Fluor® 680 | sc-514341 AF680 | 200 µg/ml | $357.00 | |||
SDSL Antibody (B-8) Alexa Fluor® 790 | sc-514341 AF790 | 200 µg/ml | $357.00 | |||
SDSL (B-8) Neutralizing Peptide | sc-514341 P | 100 µg/0.5 ml | $68.00 |