SDHC Antibody (C-2): sc-515102
- SDHC Antibody (C-2) is a mouse monoclonal IgG1 κ SDHC antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-169 representing full length SDHC of human origin
- SDHC Antibody (C-2) is recommended for detection of SDHC of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SDHC Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for SDHC Antibody (C-2) for WB applications. This reagent is now offered in a bundle with SDHC Antibody (C-2) (see ordering information below).
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SEE ALSO...
SDHC Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects SDHC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SDHC antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. SDHC protein plays a crucial role in the mitochondrial respiratory chain as a component of the succinate dehydrogenase complex, which is essential for aerobic respiration. This complex catalyzes the oxidation of succinate to fumarate, a key step in the tricarboxylic acid cycle, linking the metabolic pathways of the Krebs cycle and oxidative phosphorylation. Proper functioning of SDHC is vital for energy production in cells, and mutations in SDHC can lead to significant mitochondrial dysfunction, resulting in various hereditary disorders such as paraganglioma and Leigh Syndrome. Understanding SDHC structure and function is critical for elucidating the mechanisms underlying these diseases and developing potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SDHC Antibody (C-2) References:
- A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. | Ishii, T., et al. 2005. Cancer Res. 65: 203-9. PMID: 15665296
- New genetic causes of pheochromocytoma: current concepts and the clinical relevance. | Neumann, HP., et al. 2005. Keio J Med. 54: 15-21. PMID: 15832076
- SDHC mutations in hereditary paraganglioma/pheochromocytoma. | Müller, U., et al. 2005. Fam Cancer. 4: 9-12. PMID: 15883704
- Pheochromocytoma-associated syndromes: genes, proteins and functions of RET, VHL and SDHx. | Gimm, O. 2005. Fam Cancer. 4: 17-23. PMID: 15883706
- Carotid body paraganglioma and SDHD mutation in a Greek family. | Liapis, CD., et al. 2005. Anticancer Res. 25: 2449-52. PMID: 16080474
- Active succinate dehydrogenase (SDH) and lack of SDHD mutations in sporadic paragangliomas. | Braun, S., et al. 2005. Anticancer Res. 25: 2809-14. PMID: 16080530
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SDHC Antibody (C-2) | sc-515102 | 200 µg/ml | $322.00 | |||
SDHC Antibody (C-2): m-IgG1 BP-HRP Bundle | sc-531798 | 200 µg Ab; 20 µg BP | $361.00 | |||
SDHC Antibody (C-2) AC | sc-515102 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SDHC Antibody (C-2) HRP | sc-515102 HRP | 200 µg/ml | $322.00 | |||
SDHC Antibody (C-2) FITC | sc-515102 FITC | 200 µg/ml | $336.00 | |||
SDHC Antibody (C-2) PE | sc-515102 PE | 200 µg/ml | $349.00 | |||
SDHC Antibody (C-2) Alexa Fluor® 488 | sc-515102 AF488 | 200 µg/ml | $364.00 | |||
SDHC Antibody (C-2) Alexa Fluor® 546 | sc-515102 AF546 | 200 µg/ml | $364.00 | |||
SDHC Antibody (C-2) Alexa Fluor® 594 | sc-515102 AF594 | 200 µg/ml | $364.00 | |||
SDHC Antibody (C-2) Alexa Fluor® 647 | sc-515102 AF647 | 200 µg/ml | $364.00 | |||
SDHC Antibody (C-2) Alexa Fluor® 680 | sc-515102 AF680 | 200 µg/ml | $364.00 | |||
SDHC Antibody (C-2) Alexa Fluor® 790 | sc-515102 AF790 | 200 µg/ml | $364.00 |