SB-505124 hydrochloride hydrate (CAS 694433-59-5 free base)
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SB-505124 hydrochloride hydrate is a compound that selectively inhibits activity against certain members of the transforming growth factor-beta (TGF-β) receptor family, particularly ALK4 (activin receptor-like kinase 4), ALK5, and ALK7. These receptors are involved in the TGF-β signaling pathway, which plays a role in regulating various cellular processes, including proliferation, differentiation, and apoptosis. By inhibiting these receptors, SB-505124 hydrochloride hydrate can modulate the TGF-β signaling pathway. The hydrochloride hydrate form of SB-505124 enhances the solubility of the compound in water, facilitating its use in biological experiments. This property is particularly beneficial for in vitro studies, where the compound needs to be dissolved in aqueous media to be added to cell cultures or biochemical assays.
SB-505124 hydrochloride hydrate (CAS 694433-59-5 free base) References
- Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor. | Sapitro, J., et al. 2010. Mol Vis. 16: 1880-92. PMID: 21031133
- Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. | Quante, M., et al. 2011. Cancer Cell. 19: 257-72. PMID: 21316604
- Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method. | Hongisto, H., et al. 2017. Stem Cell Res Ther. 8: 291. PMID: 29284513
- Administration of TGF-ß Inhibitor Mitigates Radiation-induced Fibrosis in a Mouse Model. | Gans, I., et al. 2021. Clin Orthop Relat Res. 479: 468-474. PMID: 33252888
- Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model. | Liu, Z., et al. 2021. Stem Cell Res Ther. 12: 423. PMID: 34315534
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB-505124 hydrochloride hydrate, 5 mg | sc-253542 | 5 mg | $179.00 |