TGF beta Receptor Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
TGF-β RI Kinase Inhibitor VIII | 356559-20-1 | sc-203295 | 2 mg | $100.00 | 2 | |
TGF-β RI Kinase Inhibitor VIII is a selective inhibitor that targets the TGF-beta receptor signaling pathway, specifically modulating the kinase activity associated with receptor activation. Its unique structural features enable it to engage in specific molecular interactions, disrupting the phosphorylation of downstream substrates. This compound exhibits distinct reaction kinetics, allowing for fine-tuned regulation of cellular responses, thereby influencing various signaling networks and cellular behaviors. | ||||||
SB-505124 hydrochloride hydrate | 694433-59-5 free base | sc-253542 | 5 mg | $179.00 | ||
SB-505124 hydrochloride hydrate is a selective antagonist of the TGF-beta receptor, characterized by its ability to disrupt receptor dimerization and subsequent signaling cascades. Its unique binding affinity alters the conformational dynamics of the receptor, inhibiting the activation of downstream SMAD proteins. This compound demonstrates distinct interaction profiles, influencing cellular processes such as proliferation and differentiation through modulation of specific signaling pathways. | ||||||
LY2109761 | 700874-71-1 | sc-396262 sc-396262A | 1 mg 5 mg | $87.00 $270.00 | 9 | |
LY2109761 is a potent inhibitor of TGF-beta receptor signaling, exhibiting a unique mechanism of action by stabilizing the inactive conformation of the receptor. This compound selectively interferes with the phosphorylation of SMAD proteins, effectively blocking their translocation to the nucleus. Its kinetic profile reveals a rapid onset of action, with a notable impact on the receptor's ligand-binding dynamics, ultimately influencing cellular responses related to growth and tissue remodeling. | ||||||