SART-1 Antibody (F-4): sc-376288

SART-1 Antibody (F-4) is a mouse monoclonal IgG2b antibody that detects SART-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SART-1, also known as squamous cell carcinoma antigen recognized by T cells, Ara1, HOMS1, or Snu66, plays a crucial role in mRNA splicing and cell proliferation, making SART-1 vital for normal cellular function and development. SART-1 exists in two forms due to post-transcriptional modifications: SART-1(800), which is localized in the nucleus of proliferating cells, and SART-1(259), which is found in the cytosol of epithelial cancers. Notably, SART-1(259) is an essential component of the spliceosome C assembly pathway, directly influencing pre-mRNA splicing, a critical process for gene expression regulation. Furthermore, SART-1(259) contains a tumor-rejection antigen that can stimulate cytotoxic T lymphocytes in cancer patients, highlighting SART-1′s potential in immunotherapy strategies. The polymorphic variations within the SART-1 gene may also contribute to atopy, a condition characterized by allergic hypersensitivity, including eczema, asthma, and allergic conjunctivitis. With diverse roles in cellular processes and implications in cancer and allergy, anti-SART-1 antibody (F-4) serves as an invaluable tool for researchers studying these critical biological pathways.

The preferred SART-1 antibody is SART-1 Antibody (A-5): sc-376460.