SARP3 Antibody (H-6): sc-374397
- SARP3 Antibody (H-6) is a mouse monoclonal IgG2b κ SARP3 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 21-59 near the N-terminus of SARP3 of human origin
- SARP3 Antibody (H-6) is recommended for detection of SARP3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-SARP3 Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SARP3 Antibody (H-6) for WB applications. This reagent is now offered in a bundle with SARP3 Antibody (H-6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SARP3 Antibody (H-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects SARP3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SARP3 (H-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SARP3 protein, also known as frizzled-related protein 5, plays a crucial role in the Wnt signaling pathway, which is essential for various cellular processes, including cell proliferation, differentiation, and tissue homeostasis. SARP3 is primarily located in the extracellular space, where SARP3 acts as a secreted protein that interacts with Wnt ligands and frizzled receptors, modulating their activity and influencing beta-catenin levels within the cell. This regulation is vital for maintaining proper cellular communication and ensuring developmental processes occur correctly. SARP3′s influence on Wnt signaling highlights SARP3′s importance in developmental biology and potential implications in diseases where Wnt signaling is disrupted, such as cancer and degenerative disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SARP3 Antibody (H-6) References:
- Apoptosis related protein 3 is a lysosomal membrane protein. | Ding, X., et al. 2015. Biochem Biophys Res Commun. 460: 915-22. PMID: 25839652
- Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain. | Thysen, S., et al. 2016. Lab Invest. 96: 570-80. PMID: 26927515
- Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3. | Krings, JG., et al. 2021. J Allergy Clin Immunol. 148: 752-762. PMID: 33577895
- WTAP-mediated m6A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis. | An, X., et al. 2024. Exp Mol Med. 56: 156-167. PMID: 38172596
- A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. | Wang, Y., et al. 1996. J Biol Chem. 271: 4468-76. PMID: 8626800
- A frizzled homolog functions in a vertebrate Wnt signaling pathway. | Yang-Snyder, J., et al. 1996. Curr Biol. 6: 1302-6. PMID: 8939578
- A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. | Rattner, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 2859-63. PMID: 9096311
- Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. | Finch, PW., et al. 1997. Proc Natl Acad Sci U S A. 94: 6770-5. PMID: 9192640
- SARPs: a family of secreted apoptosis-related proteins. | Melkonyan, HS., et al. 1997. Proc Natl Acad Sci U S A. 94: 13636-41. PMID: 9391078
- Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family. | Leimeister, C., et al. 1998. Mech Dev. 75: 29-42. PMID: 9739103
- Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. | Sagara, N., et al. 1998. Biochem Biophys Res Commun. 252: 117-22. PMID: 9813155
- Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. | Chang, JT., et al. 1999. Hum Mol Genet. 8: 575-83. PMID: 10072424
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SARP3 Antibody (H-6) | sc-374397 | 200 µg/ml | $322.00 | |||
SARP3 Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-522721 | 200 µg Ab, 40 µg BP | $361.00 | |||
SARP3 Antibody (H-6) AC | sc-374397 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SARP3 Antibody (H-6) HRP | sc-374397 HRP | 200 µg/ml | $322.00 | |||
SARP3 Antibody (H-6) FITC | sc-374397 FITC | 200 µg/ml | $336.00 | |||
SARP3 Antibody (H-6) PE | sc-374397 PE | 200 µg/ml | $349.00 | |||
SARP3 Antibody (H-6) Alexa Fluor® 488 | sc-374397 AF488 | 200 µg/ml | $364.00 | |||
SARP3 Antibody (H-6) Alexa Fluor® 546 | sc-374397 AF546 | 200 µg/ml | $364.00 | |||
SARP3 Antibody (H-6) Alexa Fluor® 594 | sc-374397 AF594 | 200 µg/ml | $364.00 | |||
SARP3 Antibody (H-6) Alexa Fluor® 647 | sc-374397 AF647 | 200 µg/ml | $364.00 | |||
SARP3 Antibody (H-6) Alexa Fluor® 680 | sc-374397 AF680 | 200 µg/ml | $364.00 | |||
SARP3 Antibody (H-6) Alexa Fluor® 790 | sc-374397 AF790 | 200 µg/ml | $364.00 | |||
SARP3 (H-6) Neutralizing Peptide | sc-374397 P | 100 µg/0.5 ml | $69.00 |