Sar1B Antibody (AT1C7): sc-517425

Sar1B Antibody (AT1C7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Sar1B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Sar1B antibody (AT1C7) is available as the non-conjugated form, providing versatility for various experimental needs. Sar1B protein plays a crucial role in the secretory pathway of cells, specifically in the formation of transport vesicles from the endoplasmic reticulum (ER). This process is vital for proper trafficking of secretory proteins to the Golgi complex, where proteins undergo further processing and sorting. Sar1B, along with its isoform Sar1a, belongs to a family of low-molecular-weight GTPases essential for budding of COPII-coated vesicles from the ER. Mutations in the SAR1 gene can lead to serious health issues, such as Anderson′s disease, a rare autosomal recessive disorder characterized by lipid malabsorption, chronic diarrhea, and failure to thrive in childhood. Sar1B′s ability to facilitate vesicular transport underscores its importance in maintaining cellular homeostasis and proper physiological function, making Sar1B (AT1C7) monoclonal antibody an invaluable tool for researchers studying cellular transport mechanisms and related disorders.

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Sar1B Antibody (AT1C7) References:

1. The intracellular transport of chylomicrons requires the small GTPase, Sar1b.  |  Shoulders, CC., et al. 2004. Curr Opin Lipidol. 15: 191-7. PMID: 15017362
2. Sequence identification, tissue distribution, mapping and polymorphism of the porcine sar1b gene.  |  Wang, XM., et al. 2006. Anim Biotechnol. 17: 99-107. PMID: 16621763
3. Anderson or chylomicron retention disease: molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein.  |  Charcosset, M., et al. 2008. Mol Genet Metab. 93: 74-84. PMID: 17945526
4. Anderson's disease (chylomicron retention disease): a new mutation in the SARA2 gene associated with muscular and cardiac abnormalities.  |  Silvain, M., et al. 2008. Clin Genet. 74: 546-52. PMID: 18786134
5. Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments.  |  Kuge, O., et al. 1994. J Cell Biol. 125: 51-65. PMID: 8138575
6. Transcriptional studies on yeast SEC genes provide no evidence for regulation at the transcriptional level.  |  Vahlensieck, Y., et al. 1995. Yeast. 11: 901-11. PMID: 8533466
7. Sec31 encodes an essential component of the COPII coat required for transport vesicle budding from the endoplasmic reticulum.  |  Salama, NR., et al. 1997. Mol Biol Cell. 8: 205-17. PMID: 9190202
8. Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex.  |  Nickel, W., et al. 1998. Semin Cell Dev Biol. 9: 493-501. PMID: 9835636
9. Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase.  |  Saito, Y., et al. 1999. J Biochem. 125: 130-7. PMID: 9880808

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sar1B Antibody (AT1C7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Sar1B Antibody (AT1C7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sar1B Antibody (AT1C7) Specifications

Alternate Product Name: Sar1B

Product Clone Name: AT1C7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-198

Epitope Target: Sar1B

Epitope Species: human

Product Reactivity/Detection: Sar1B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 1% glycerol and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Sar1B Antibody (AT1C7): N/A