SAPAP1 Antibody (21): sc-136524
- SAPAP1 Antibody (21) is a mouse monoclonal IgG2b κ SAPAP1 antibody provided at 200 µg/ml
- raised against amino acids 261-348 of SAPAP1 of human origin
- recommended for detection of SAPAP1 of mouse, rat and human origin by WB and IP; also reactive with additional species, including canine
- available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SAPAP1 Antibody (21). This work is in progress.
QUICK LINKS
SAPAP1 Antibody (21) is a mouse monoclonal IgG2b kappa light chain antibody that detects SAPAP1 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-SAPAP1 antibody (21) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). SAPAP1 protein plays a crucial role in organizing protein-signaling complexes at neuronal synapses, functioning as a key component of the postsynaptic density. SAPAP1 is part of the postsynaptic density-95 (PSD-95)/SAP90 family of membrane-associated guanylate kinase (MAGUK) proteins, which serve as multimodular scaffolds that facilitate the assembly of signaling complexes essential for synaptic transmission and plasticity. SAPAP1′s interaction with guanylate kinase-associated protein (GKAP) is particularly significant, as GKAP is localized in the postsynaptic density of glutamatergic synapses, where GKAP helps anchor other signaling molecules, thereby influencing synaptic strength and stability. This interaction underscores SAPAP1′s importance in maintaining the structural integrity and functional efficacy of synapses, which is vital for processes such as learning and memory.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SAPAP1 Antibody (21) References:
- Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95. | Passafaro, M., et al. 1999. Nat Neurosci. 2: 1063-9. PMID: 10570482
- Activation of channel activity of the NMDA receptor-PSD-95 complex by guanylate kinase-associated protein (GKAP). | Yamada, Y., et al. 1999. FEBS Lett. 458: 295-8. PMID: 10570927
- An intramolecular interaction between Src homology 3 domain and guanylate kinase-like domain required for channel clustering by postsynaptic density-95/SAP90. | Shin, H., et al. 2000. J Neurosci. 20: 3580-7. PMID: 10804199
- GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. | Kim, E., et al. 1997. J Cell Biol. 136: 669-78. PMID: 9024696
- Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90. | Naisbitt, S., et al. 1997. J Neurosci. 17: 5687-96. PMID: 9221768
- BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. | Deguchi, M., et al. 1998. J Biol Chem. 273: 26269-72. PMID: 9756850
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAPAP1 Antibody (21) | sc-136524 | 200 µg/ml | $322.00 | |||
SAPAP1 Antibody (21) AC | sc-136524 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SAPAP1 Antibody (21) HRP | sc-136524 HRP | 200 µg/ml | $322.00 |