SAPAP1 Activators
SAPAP1 Activators belong to a distinctive chemical class that interacts with the Synapse-Associated Protein 90/Postsynaptic Density-95-Associated Protein 1 (SAPAP1). SAPAP1 is a key component in the regulation of synaptic function and plasticity within the central nervous system. As a member of the membrane-associated guanylate kinase (MAGUK) family, SAPAP1 plays a crucial role in the organization and stabilization of the postsynaptic density (PSD) at excitatory synapses. It is primarily expressed in the postsynaptic compartments of neurons, where it orchestrates the assembly of signaling complexes that contribute to the proper functioning of neuronal circuits.
SAPAP1 Activators modulate the activity of SAPAP1, influencing its interactions with other synaptic proteins and thereby impacting synaptic transmission. The activation of SAPAP1 is thought to initiate a cascade of molecular events that influence the structural and functional dynamics of synapses, ultimately contributing to the refinement of neural circuits. These activators may exert their effects through various mechanisms, such as altering the conformation of SAPAP1 or facilitating its association with specific binding partners. The intricate interplay between SAPAP1 and its activators underscores the complexity of synaptic regulation, shedding light on the delicate balance required for proper neuronal communication and network connectivity in the central nervous system. Understanding the mechanisms by which SAPAP1 Activators operate holds promise for unraveling novel insights into synaptic physiology and potential avenues for future research in neuroscience.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, a potent adenylyl cyclase activator, can increase the production of cAMP. SAPAP1, being directly associated with AMPA receptors which are regulated by PKA (a cAMP-dependent protein kinase), can be functionally enhanced when cAMP levels rise. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram, a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), prevents the degradation of cAMP thereby increasing its levels. This can indirectly enhance SAPAP1 functionality by amplifying PKA activation due to increased cAMP. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog. It activates cAMP-dependent protein kinases, which can enhance the functional activity of SAPAP1 by modulating the AMPA receptors with which SAPAP1 interacts. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). By inhibiting these phosphatases, it can increase phosphorylation events, thus indirectly enhancing SAPAP1 by affecting the phosphorylation state of associated AMPA receptors. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Picrotoxin is a GABAA receptor antagonist. By inhibiting this inhibitory receptor, it can indirectly enhance the activity of SAPAP1 through enhancing glutamatergic transmission, thus driving increased AMPA receptor activity. | ||||||
Lamotrigine | 84057-84-1 | sc-201079 sc-201079A | 10 mg 50 mg | $120.00 $486.00 | 1 | |
Lamotrigine inhibits voltage-gated sodium channels, thereby reducing glutamate release. This can indirectly enhance SAPAP1's function by modulating the glutamatergic activity that influences AMPA receptor function. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $208.00 | 2 | |
CNQX is a potent AMPA receptor antagonist. While it doesn’t directly enhance SAPAP1, it provides a crucial control for studies. By antagonizing the AMPA receptors with which SAPAP1 interacts, it can provide a baseline for SAPAP1's functional activity in the absence of AMPA receptor activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it can alter downstream signaling events that influence AMPA receptor trafficking and function, thereby indirectly impacting SAPAP1 activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a potent PKA inhibitor. By inhibiting PKA, it can control for the effects of cAMP elevation on SAPAP1's activity via modulating AMPA receptor function. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $136.00 | 20 | |
KN-62 is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). The inhibition of CaMKII can lead to modulation of AMPA receptor activity, potentially influencing SAPAP1 functionality. | ||||||