SAP 62 Antibody (32J-7): sc-101138
- SAP 62 Antibody (32J-7) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant SAP 62 of human origin
- recommended for detection of SAP 62 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SAP 62 Antibody (32J-7). This work is in progress.
SAP 62 Antibody (32J-7) is a mouse monoclonal IgG2b antibody that detects SAP 62 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SAP 62, also known as SF3A2, PRP11, PRPF11, or SF3a66, is a 464 amino acid protein characterized by a matrin-type zinc finger and is a crucial component of the SF3A splicing factor complex, which is essential for pre-mRNA splicing. SAP 62 is primarily localized in the nucleus, where SAP 62 plays a vital role in the assembly of the U2 small nuclear ribonucleoprotein (snRNP) complex, facilitating the conversion of the inactive 15S U2 snRNP into the active 17S form that is directly involved in splicing events. SAP 62 functions as the second subunit of the SF3A complex, engaging with subunit 1 (SAP 114) through its N-terminus while utilizing its zinc finger domain to bind to the 15S U2 snRNP. Beyond involvement in RNA splicing, SAP 62 is also believed to function independently as a microtubule-binding protein, highlighting SAP 62′s multifaceted role in cellular processes. Anti-SAP 62 antibody (32J-7) is an invaluable tool for researchers studying the intricacies of RNA processing and the broader implications of splicing factors in gene regulation and cellular function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAP 62 Antibody (32J-7) | sc-101138 | 100 µg/ml | $333.00 |