SAP 49 Antibody (D-11): sc-514007
- SAP 49 Antibody (D-11) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- raised against amino acids 145-216 mapping within an internal region of SAP 49 of human origin
- recommended for detection of SAP 49 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for SAP 49 Antibody (D-11) for WB applications. This reagent is now offered in a bundle with SAP 49 Antibody (D-11) (see ordering information below).
SAP 49 Antibody (D-11) is a mouse monoclonal IgG3 antibody that detects SAP 49 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SAP 49 is a crucial component of the U2 small nuclear ribonucleoprotein (snRNP) complex, which is essential for the assembly of the spliceosome, a vital molecular machine responsible for the splicing of pre-mRNA. SAP 49′s primary function involves interaction with other spliceosomal proteins, including SAP 145, which is critical for the proper formation and stability of the spliceosome. Notably, the interaction between SAP 49 and SAP 145 is mediated by the amino-terminus of SAP 49, which harbors two RNA-recognition motifs that facilitate binding to both U2 snRNP and pre-mRNA. This interaction is significant as SAP 49 plays a pivotal role in anchoring the U2 snRNP to the branch site during splicing, thereby ensuring the accuracy and efficiency of mRNA processing. Anti-SAP 49 antibody (D-11) is an invaluable tool for researchers studying the dynamics of spliceosome assembly and the intricate processes of gene expression regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAP 49 Antibody (D-11) | sc-514007 | 200 µg/ml | $322.00 | |||
SAP 49 Antibody (D-11): m-IgG3 BP-HRP Bundle | sc-550515 | 200 µg Ab; 40 µg BP | $361.00 |