SAP 30 Antibody (CA14): sc-130425

SAP 30 Antibody (CA14) is a mouse monoclonal IgG2b kappa light chain antibody that detects SAP 30 protein of human origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SAP 30 antibody (CA14) is available as a non-conjugated format. SAP 30 protein plays a crucial role in gene expression regulation through chromatin remodeling involvement. SAP 30 (CA14) antibody recognizes a component of the mSin3 corepressor complex, essential for histone deacetylation and transcriptional silencing. SAP 30 interaction with histone deacetylases HDAC1 and HDAC2, along with other associated proteins, facilitates chromatin structure alteration, making SAP 30 a key player in dynamic transcription regulation. Understanding SAP 30 function is vital, as SAP 30 contributes to cellular homeostasis maintenance and has implications in various diseases where gene expression becomes dysregulated. Anti-SAP 30 antibody (CA14) enables researchers to gain insights into transcriptional regulation mechanisms and chromatin dynamics in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SAP 30 Antibody (CA14) References:

1. The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.  |  Seelig, HP., et al. 1995. Arthritis Rheum. 38: 1389-99. PMID: 7575689
2. Nucleosome structural changes due to acetylation.  |  Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
3. A positive role for histone acetylation in transcription factor access to nucleosomal DNA.  |  Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
4. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.  |  Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
5. Repression and activation by multiprotein complexes that alter chromatin structure.  |  Kingston, RE., et al. 1996. Genes Dev. 10: 905-20. PMID: 8608939
6. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.  |  Zhang, Y., et al. 1997. Cell. 89: 357-64. PMID: 9150135
7. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.  |  Zhang, Y., et al. 1998. Mol Cell. 1: 1021-31. PMID: 9651585
8. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.  |  Zhang, Y., et al. 1998. Cell. 95: 279-89. PMID: 9790534

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SAP 30 Antibody (CA14) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SAP 30 Antibody (CA14) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SAP 30 Antibody (CA14) Specifications

Alternate Product Name: SAP 30

Product Clone Name: CA14

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 131-220

Epitope Target: SAP 30

Epitope Species: human

Product Reactivity/Detection: SAP 30

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SAP 30 Antibody (CA14): N/A