Molecular structure of Sandoz 58-035, CAS Number: 78934-83-5
Sandoz 58-035 (CAS 78934-83-5)
See product citations (11)
Alternate Names:
Sandoz 58-035 is also known as SA 58-035.
Application:
Sandoz 58-035 is an inhibitor of SOAT (Acyl-CoA cholesterol acyltransferase/ACAT).
CAS Number:
78934-83-5
Purity:
≥98%
Molecular Weight:
465.79
Molecular Formula:
C30H47NOSi
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sandoz 58-035 is an inhibitor of Acyl-CoA cholesterol acyltransferase (ACAT). Sandoz 58-035 also inhibits the accumulation of cholesteryl esters and inhibits the esterification of cholesterol by 95% in arterial smooth muscle cells in culture. Sandoz 58-035 does not affect the triglyceride metabolism by the gut. Sandoz 58-035 was used to induce simultaneous activation of unfolded protein response (UPR) and pattern recognition receptors (PRRs) in mouse peritoneal macrophages. Sandoz 58-035 is also known as SA 58-035, and 3-[Decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenethyl]propanamide.
Sandoz 58-035 (CAS 78934-83-5) References
- Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. | Wiegand, V., et al. 2003. FASEB J. 17: 782-4. PMID: 12594172
- Role of cholesterol ester pathway in the control of cell cycle in human aortic smooth muscle cells. | Batetta, B., et al. 2003. FASEB J. 17: 746-8. PMID: 12594184
- Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages. | Freeman, NE., et al. 2005. J Lipid Res. 46: 1933-43. PMID: 15995174
- Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts. | Diaz, G., et al. 2008. Histochem Cell Biol. 129: 611-21. PMID: 18297300
- Luminol electrochemiluminescence for the analysis of active cholesterol at the plasma membrane in single mammalian cells. | Ma, G., et al. 2013. Anal Chem. 85: 3912-7. PMID: 23527944
- Synthesis, biological evaluation, and molecular docking studies of xanthone sulfonamides as ACAT inhibitors. | Li, X., et al. 2015. Chem Biol Drug Des. 85: 394-403. PMID: 25146964
- Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus. | Saito, K., et al. 2015. J Virol. 89: 2220-32. PMID: 25473062
- The measurement of high-density lipoprotein mediated cholesterol efflux from macrophage cells by liquid chromatography tandem mass spectrometry. | Wang, M., et al. 2014. Cell Physiol Biochem. 34: 1901-11. PMID: 25503882
- Cholesterol esterification plays a major role in determining low-density-lipoprotein receptor activity in primary monolayer cultures of rat hepatocytes. | Salter, AM., et al. 1989. Biochem J. 263: 255-60. PMID: 2604696
- Cholesteryl ester cycle in cultured hepatoma cells. | Glick, JM., et al. 1987. Atherosclerosis. 64: 223-30. PMID: 3606720
- Inhibition of acyl coenzyme A:cholesterol acyl transferase in J774 macrophages enhances down-regulation of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase and prevents low density lipoprotein-induced cholesterol accumulation. | Tabas, I., et al. 1986. J Biol Chem. 261: 3147-55. PMID: 3949765
- Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035. | Ross, AC., et al. 1984. J Biol Chem. 259: 815-9. PMID: 6693397
- Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol. | Warner, GJ., et al. 1995. J Biol Chem. 270: 5772-8. PMID: 7890706
- Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester. | Wu, X., et al. 1994. J Biol Chem. 269: 12375-82. PMID: 8163541
- Regulation of low density lipoprotein receptor and 3-hydroxy-3-methyl-glutaryl-CoA reductase activities are differentially affected in Niemann-Pick type C and type D fibroblasts. | Sidhu, HS., et al. 1993. Biochem Cell Biol. 71: 467-74. PMID: 8192899
- New model to study cholesterol uptake in the human intestine in vitro. | Sviridov, DD., et al. 1993. J Lipid Res. 34: 331-9. PMID: 8429265
- Interleukin 1 stimulates cholesterol esterification and cholesterol deposition in J774 monocytes-macrophages. | Mazière, C., et al. 1996. Biochim Biophys Acta. 1300: 30-4. PMID: 8608158
Inhibitor of:
SOAT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sandoz 58-035, 5 mg | sc-215839 | 5 mg | $202.00 | |||
Sandoz 58-035, 25 mg | sc-215839A | 25 mg | $836.00 |