Sall4 Antibody (EE-30): sc-101147

Sall4 Antibody (EE-30) is a mouse monoclonal IgG1 kappa light chain antibody that detects Sall4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Sall4 antibody (EE-30) is available in a non-conjugated form, allowing for versatile experimental use. Sall4, a member of the sal-like family of proteins, plays a crucial role in embryonic development and stem cell maintenance by acting as a transcriptional regulator. Sall4 function is particularly important as Sall4 is involved in the regulation of pluripotency and differentiation of stem cells, which has significant implications for developmental biology and regenerative medicine. Sall4 is primarily localized in the nucleus, where Sall4 interacts with various transcription factors to modulate gene expression essential for early embryonic development. Understanding Sall4′s role in these processes can provide insights into developmental disorders and potential therapeutic targets for regenerative therapies.

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Sall4 Antibody (EE-30) References:

1. Zinc finger protein sall2 is not essential for embryonic and kidney development.  |  Sato, A., et al. 2003. Mol Cell Biol. 23: 62-9. PMID: 12482961
2. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology.  |  Nielsen, TO., et al. 2003. Am J Pathol. 163: 1449-56. PMID: 14507652
3. Genetic determination of nephrogenesis: the Pax/Eya/Six gene network.  |  Brodbeck, S. and Englert, C. 2004. Pediatr Nephrol. 19: 249-55. PMID: 14673635
4. The Sall3 locus is an epigenetic hotspot of aberrant DNA methylation associated with placentomegaly of cloned mice.  |  Ohgane, J., et al. 2004. Genes Cells. 9: 253-60. PMID: 15005712
5. p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP).  |  Li, D., et al. 2004. Mol Cell Biol. 24: 3885-93. PMID: 15082782
6. Identification of genes differentially expressed in testes containing carcinoma in situ.  |  Hoei-Hansen, CE., et al. 2004. Mol Hum Reprod. 10: 423-31. PMID: 15123780
7. Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin.  |  Sato, A., et al. 2004. Biochem Biophys Res Commun. 319: 103-13. PMID: 15158448
8. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.  |  Takasato, M., et al. 2004. Mech Dev. 121: 547-57. PMID: 15172686
9. [Congenital fibrosis of extraocular muscles (CFEOM) and other phenotypes of congenital cranial dysinnervation syndromes (CCDD)].  |  Hanisch, F., et al. 2005. Nervenarzt. 76: 395-402. PMID: 15221064
10. Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality.  |  Parrish, M., et al. 2004. Mol Cell Biol. 24: 7102-12. PMID: 15282310
11. Novel mutations in the gene SALL4 provide further evidence for acro-renal-ocular and Okihiro syndromes being allelic entities, and extend the phenotypic spectrum.  |  Borozdin, W., et al. 2004. J Med Genet. 41: e102. PMID: 15286162
12. Mutations in SALL4 in malformed father and daughter postulated previously due to reflect mutagenesis by thalidomide.  |  Kohlhase, J. and Holmes, LB. 2004. Birth Defects Res A Clin Mol Teratol. 70: 550-1. PMID: 15329836
13. SALL4 deletions are a common cause of Okihiro and acro-renal-ocular syndromes and confirm haploinsufficiency as the pathogenic mechanism.  |  Borozdin, W., et al. 2004. J Med Genet. 41: e113. PMID: 15342710
14. No evidence of SALL4-mutations in isolated sporadic duane retraction 'syndrome' (DURS).  |  Wabbels, BK., et al. 2004. Am J Med Genet A. 131: 216-8. PMID: 15386473
15. [Clinical and molecular genetic findings in isolated sporadic Duane syndrome].  |  Wabbels, BK., et al. 2004. Klin Monbl Augenheilkd. 221: 849-53. PMID: 15499520

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sall4 Antibody (EE-30) has 61 citations in a variety of scientific publications.

Primary antibodies like Anti-Sall4 Antibody (EE-30) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sall4 Antibody (EE-30) Specifications

Alternate Product Name: Sall4

Product Clone Name: EE-30

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 954-1054

Epitope Target: Sall4

Epitope Species: human

Product Reactivity/Detection: Sall4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 61 citations in various scientific publications

Available Conjugates/Forms for Sall4 Antibody (EE-30): N/A