Sall2 Antibody (PL-A12): sc-135619

Sall2 Antibody (PL-A12) is a mouse monoclonal IgG2a kappa light chain antibody that detects Sall2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Sall2 antibody (PL-A12) is available as a non-conjugated format, providing researchers with a versatile tool for studying this important protein. Sall2 (PL-A12) antibody enables investigation of Sall2′s crucial role in regulating cell growth and survival, functioning as a p53-independent modulator of p21 and BAX, which are key players in the cell cycle and apoptosis. This regulation is particularly significant in various tissues, including the brain, heart, kidney, and pancreas, where Sall2 is expressed. Understanding Sall2′s function is vital, as dysregulation can contribute to various diseases, including cancer. Additionally, Sall2 and its homolog Sall1 are expressed in distinct regions of the fetal brain, suggesting involvement in the development of specific neuronal populations. Sall2 (PL-A12) monoclonal antibody helps researchers gain insights into the molecular mechanisms underlying cell growth and differentiation, as well as the potential implications of Sall2 in developmental biology and disease pathology.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Sall2 Antibody (PL-A12) References:

1. Zinc finger protein sall2 is not essential for embryonic and kidney development.  |  Sato, A., et al. 2003. Mol Cell Biol. 23: 62-9. PMID: 12482961
2. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology.  |  Nielsen, TO., et al. 2003. Am J Pathol. 163: 1449-56. PMID: 14507652
3. Genetic determination of nephrogenesis: the Pax/Eya/Six gene network.  |  Brodbeck, S. and Englert, C. 2004. Pediatr Nephrol. 19: 249-55. PMID: 14673635
4. The Sall3 locus is an epigenetic hotspot of aberrant DNA methylation associated with placentomegaly of cloned mice.  |  Ohgane, J., et al. 2004. Genes Cells. 9: 253-60. PMID: 15005712
5. p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP).  |  Li, D., et al. 2004. Mol Cell Biol. 24: 3885-93. PMID: 15082782
6. Identification of genes differentially expressed in testes containing carcinoma in situ.  |  Hoei-Hansen, CE., et al. 2004. Mol Hum Reprod. 10: 423-31. PMID: 15123780
7. Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin.  |  Sato, A., et al. 2004. Biochem Biophys Res Commun. 319: 103-13. PMID: 15158448
8. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.  |  Takasato, M., et al. 2004. Mech Dev. 121: 547-57. PMID: 15172686
9. [Congenital fibrosis of extraocular muscles (CFEOM) and other phenotypes of congenital cranial dysinnervation syndromes (CCDD)].  |  Hanisch, F., et al. 2005. Nervenarzt. 76: 395-402. PMID: 15221064
10. Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality.  |  Parrish, M., et al. 2004. Mol Cell Biol. 24: 7102-12. PMID: 15282310
11. Novel mutations in the gene SALL4 provide further evidence for acro-renal-ocular and Okihiro syndromes being allelic entities, and extend the phenotypic spectrum.  |  Borozdin, W., et al. 2004. J Med Genet. 41: e102. PMID: 15286162
12. Mutations in SALL4 in malformed father and daughter postulated previously due to reflect mutagenesis by thalidomide.  |  Kohlhase, J. and Holmes, LB. 2004. Birth Defects Res A Clin Mol Teratol. 70: 550-1. PMID: 15329836
13. SALL4 deletions are a common cause of Okihiro and acro-renal-ocular syndromes and confirm haploinsufficiency as the pathogenic mechanism.  |  Borozdin, W., et al. 2004. J Med Genet. 41: e113. PMID: 15342710
14. No evidence of SALL4-mutations in isolated sporadic duane retraction 'syndrome' (DURS).  |  Wabbels, BK., et al. 2004. Am J Med Genet A. 131: 216-8. PMID: 15386473
15. [Clinical and molecular genetic findings in isolated sporadic Duane syndrome].  |  Wabbels, BK., et al. 2004. Klin Monbl Augenheilkd. 221: 849-53. PMID: 15499520

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sall2 Antibody (PL-A12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Sall2 Antibody (PL-A12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sall2 Antibody (PL-A12) Specifications

Alternate Product Name: Sall2

Product Clone Name: PL-A12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-199

Epitope Target: Sall2

Epitope Species: human

Product Reactivity/Detection: Sall2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Sall2 Antibody (PL-A12): N/A