SAF-B Antibody (4D6): sc-135618
- SAF-B Antibody (4D6) is a mouse monoclonal IgG2b κ provided at 100 µg/ml
- raised against recombinant SAF-B protein of human origin
- recommended for detection of SAF-B of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SAF-B Antibody (4D6). This work is in progress.
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SAF-B Antibody (4D6) is a mouse monoclonal IgG2b antibody that detects SAF-B in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SAF-B, also known as scaffold attachment factor B, plays a crucial role in gene expression regulation by binding to matrix- or scaffold-associating regions on DNA, thereby influencing chromatin organization and transcriptional machinery. SAF-B is primarily located in the nucleus, where SAF-B exhibits a speckled distribution under normal conditions but can be recruited to larger nuclear granules, known as perichromatin granules, in response to stressors such as heat shock. SAF-B′s ability to interact with RNA polymerase II and serine-/arginine-rich RNA processing factors underscores SAF-B′s importance in pre-mRNA processing and transport, which are vital for proper gene expression. Additionally, SAF-B′s interaction with estrogen receptor highlights SAF-B′s potential involvement in breast cancer biology, as SAF-B is expressed at varying levels in several breast cancer cell lines, suggesting a role in cellular proliferation and division. With diverse applications and significant biological functions, anti-SAF-B antibody (4D6) serves as an essential tool for researchers studying gene regulation and cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAF-B Antibody (4D6) | sc-135618 | 100 µg/ml | $339.00 |