Sacsin Antibody (F-1): sc-365585
- Sacsin Antibody (F-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 781-1080 mapping within an internal region of Sacsin of human origin
- recommended for detection of Sacsin of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Sacsin Antibody (F-1) for WB applications. These reagents are now offered in bundles with Sacsin Antibody (F-1) (see ordering information below).
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Sacsin Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects Sacsin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sacsin is a crucial protein involved in chaperone-mediated protein folding, primarily expressed in the central nervous system, with additional expression noted in skeletal muscle and pancreatic tissues. Sacsin′s structure contains seven nuclear localization signals, three coiled-coil domains, and two leucine zipper motifs, alongside the DnaJ motif and a hydrophobic domain located in its C-terminal region. These structural features are essential for Sacsin′s function in facilitating proper protein folding and preventing aggregation, which is vital for maintaining cellular homeostasis. Defects in the SACS gene, which encodes Sacsin, can lead to autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early onset symptoms such as reduced motor-nerve velocity and absent sensory-nerve conduction, highlighting Sacsin′s importance in neurological health. The prevalence of ARSACS in the Charlevoix-Saguenay-Lac-Saint-Jean region of Quebec underscores the critical role that Sacsin plays in the nervous system, making anti-Sacsin antibody (F-1) an invaluable tool for researchers studying this protein and its associated pathologies.
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Sacsin Antibody (F-1) References:
- Sacsinopathies: sacsin-related ataxia. | Takiyama, Y. 2007. Cerebellum. 6: 353-9. PMID: 17853117
- The sacsin repeating region (SRR): a novel Hsp90-related supra-domain associated with neurodegeneration. | Anderson, JF., et al. 2010. J Mol Biol. 400: 665-74. PMID: 20488193
- High-Throughput Screening for Ligands of the HEPN Domain of Sacsin. | Li, X., et al. 2015. PLoS One. 10: e0137298. PMID: 26366743
- Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics. | Gentil, BJ., et al. 2019. FASEB J. 33: 2982-2994. PMID: 30332300
- Assessment of Sacsin Turnover in Patients With ARSACS: Implications for Molecular Diagnosis and Pathogenesis. | Longo, F., et al. 2021. Neurology. 97: e2315-e2327. PMID: 34649874
- Genetics of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) and Role of Sacsin in Neurodegeneration. | Bagaria, J., et al. 2022. Int J Mol Sci. 23: PMID: 35008978
- Sacsin Deletion Induces Aggregation of Glial Intermediate Filaments. | Murtinheira, F., et al. 2022. Cells. 11: PMID: 35053415
- The ARSACS disease protein sacsin controls lysosomal positioning and reformation by regulating microtubule dynamics. | Francis, V., et al. 2022. J Biol Chem. 298: 102320. PMID: 35933016
- Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization. | Romano, LEL., et al. 2022. Cell Rep. 41: 111580. PMID: 36323248
- A Novel Mutation in Sacsin, p.Val1335IIe, May Cause Late-Onset Sacsinopathy Due to Haploinsufficiency. | Kim, D., et al. 2023. Curr Issues Mol Biol. 45: 9917-9925. PMID: 38132465
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sacsin Antibody (F-1) | sc-365585 | 200 µg/ml | $322.00 | |||
Sacsin Antibody (F-1): m-IgG Fc BP-HRP Bundle | sc-540351 | 200 µg Ab; 10 µg BP | $361.00 | |||
Sacsin Antibody (F-1): m-IgG1 BP-HRP Bundle | sc-542058 | 200 µg Ab; 20 µg BP | $361.00 |