SAA Antibody (115): sc-59679

SAA Antibody (115) is a mouse monoclonal IgG1 kappa light chain antibody that detects the SAA protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SAA antibody (115) is available as the non-conjugated format. The serum amyloid A (SAA) family of proteins plays a crucial role in the body′s response to inflammation and infection, as SAA proteins are major acute-phase proteins rapidly produced by the liver in response to inflammatory stimuli. This response is vital for the recruitment of immune cells to sites of injury or infection, thereby facilitating tissue repair and modulating the immune response. SAA proteins, particularly SAA1 and SAA2, are precursors to amyloid A protein, which can accumulate in tissues and lead to amyloidosis if produced in excess. The SAA gene family, located on human chromosome 11p15.1, consists of multiple genes that exhibit allelic variation and high homology, with SAA1 and SAA2 being the primary acute-phase reactants. Understanding SAA protein function is essential for elucidating SAA′s role in various inflammatory diseases and conditions, making SAA monoclonal antibody (115) a valuable tool for researchers studying these processes.

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SAA Antibody (115) References:

1. Purification and characterization of the serum amyloid A3 enhancer factor.  |  Bing, Z., et al. 1999. J Biol Chem. 274: 24649-56. PMID: 10455131
2. Role of serum amyloid A during metabolism of acute-phase HDL by macrophages.  |  Artl, A., et al. 2000. Arterioscler Thromb Vasc Biol. 20: 763-72. PMID: 10712402
3. Serum amyloid A is an activator of PMN antimicrobial functions: induction of degranulation, phagocytosis, and enhancement of anti-Candida activity.  |  Badolato, R., et al. 2000. J Leukoc Biol. 67: 381-6. PMID: 10733099
4. Human serum amyloid A protein. Complete amino acid sequence of a new variant.  |  Beach, CM., et al. 1992. Biochem J. 282 (Pt 2): 615-20. PMID: 1546977
5. Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person.  |  Kluve-Beckerman, B., et al. 1988. J Clin Invest. 82: 1670-5. PMID: 3183061
6. DNA sequence evidence for polymorphic forms of human serum amyloid A (SAA).  |  Kluve-Beckerman, B., et al. 1986. Biochem Genet. 24: 795-803. PMID: 3800865
7. Organization of the region encompassing the human serum amyloid A (SAA) gene family on chromosome 11p15.1.  |  Sellar, GC., et al. 1994. Genomics. 23: 492-5. PMID: 7835903

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SAA Antibody (115) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-SAA Antibody (115) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SAA Antibody (115) Specifications

Alternate Product Name: Serum Amyloid A1 / A2

Product Clone Name: 115

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: SAA

Epitope Species: human

Product Reactivity/Detection: natural and recombinant SAA

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for SAA Antibody (115): N/A