S-100P Antibody (B-10): sc-374547

S-100P Antibody (B-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects S-100P protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-S-100P antibody (B-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. S-100P, a member of the S-100 family, plays a crucial role in regulating intracellular calcium levels and is involved in various cellular processes, including cell growth, division, and migration. S-100P functions as a survival factor in tumors, binding to and modulating effector proteins′ activity, thereby influencing tumor progression. S-100P interacts with the receptor for advanced glycation end products (RAGE), which activates signaling pathways promoting cell proliferation and survival, suggesting an autocrine mechanism that enhances tumorigenesis. S-100P forms stable homodimers through hydrophobic interactions essential for biological activity, as these dimers are necessary to exert effects. Regulation of S-100P expression by synthetic androgens, such as R1881, further underscores significance in cancer biology, making S-100P (B-10) monoclonal antibody a valuable tool for researchers studying roles in various pathological conditions.

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S-100P Antibody (B-10) References:

1. Identification of hydrophobic amino acid residues involved in the formation of S100P homodimers in vivo.  |  Koltzscher, M. and Gerke, V. 2000. Biochemistry. 39: 9533-9. PMID: 10924150
2. Conformational and thermodynamic properties of peptide binding to the human S100P protein.  |  Gribenko, AV., et al. 2002. Protein Sci. 11: 1367-75. PMID: 12021435
3. S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE).  |  Arumugam, T., et al. 2004. J Biol Chem. 279: 5059-65. PMID: 14617629
4. Purification and characterization of a new member of the S-100 protein family from human placenta.  |  Emoto, Y., et al. 1992. Biochem Biophys Res Commun. 182: 1246-53. PMID: 1540168
5. S100P is selectively upregulated in tumor cell lines challenged with DNA cross-linking agents.  |  Jiang, F., et al. 2005. Leuk Res. 29: 1181-90. PMID: 15936073
6. Expression of S100P protein correlates with and contributes to the tumorigenic capacity of HeLa cervical carcinoma cells.  |  Gibadulinová, A., et al. 2005. Oncol Rep. 14: 575-82. PMID: 16012747
7. Expression of S100P gene in cervical carcinoma cells is independent of E7 human papillomavirus oncogene.  |  Jakubícková, L., et al. 2005. Acta Virol. 49: 133-7. PMID: 16047742
8. S100P promotes pancreatic cancer growth, survival, and invasion.  |  Arumugam, T., et al. 2005. Clin Cancer Res. 11: 5356-64. PMID: 16061848
9. Dimerization and ion binding properties of S100P protein.  |  Tutar, Y. 2006. Protein Pept Lett. 13: 301-6. PMID: 16515459
10. An immunocytochemical comparison of glial fibrillary acidic protein, S-100p and vimentin in human glial tumors.  |  Nakopoulou, L., et al. 1990. J Neurooncol. 8: 33-40. PMID: 2319288
11. Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder.  |  Paner, GP., et al. 2014. Hum Pathol. 45: 1473-82. PMID: 24780825
12. Regulation of S100P expression by androgen.  |  Averboukh, L., et al. 1996. Prostate. 29: 350-5. PMID: 8977631

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-S-100P Antibody (B-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-S-100P Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

S-100P Antibody (B-10) Specifications

Alternate Product Name: S100 protein P (S100P)

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 9-95

Epitope Target: S-100P

Epitope Species: human

Product Reactivity/Detection: S-100P

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for S-100P Antibody (B-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin