S-100 β chain Antibody (9A11B9): sc-81709

S-100 β chain Antibody (9A11B9) is a mouse monoclonal IgG1 antibody that detects S-100 β chain in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). S-100 β chain plays a crucial role in various cellular processes, including the regulation of cell cycle progression and differentiation, which are vital for maintaining normal cellular function and tissue homeostasis. S-100 β chain is involved in the activation of calcium-induced calcium release, a mechanism essential for neurotransmitter release and neuronal signaling in the nervous system. S-100 β chain inhibits microtubule assembly and protein kinase C-mediated phosphorylation, further underscoring regulatory functions in cellular signaling pathways. S-100 β chain is primarily localized in the cytoplasm and nuclei of astrocytes, Schwann cells, and certain tumors, including ependymomas and astrogliomas, making S-100 β chain a significant marker in neurobiology and oncology. With diverse roles and widespread expression in various tissues, S-100 β chain serves as a valuable target for research and diagnostic applications, providing insights into both normal physiology and pathological conditions.

The preferred S-100 α/β chain antibody is S-100 α/β chain Antibody (B32.1): sc-58839.