RXRα Antibody (C-7): sc-515928
- RXRα Antibody (C-7) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-27 at the N-terminus of RXRα of human origin
- recommended for detection of RXRα of human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-515928 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for RXRα Antibody (C-7) for WB applications. This reagent is now offered in a bundle with RXRα Antibody (C-7) (see ordering information below).
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RXRα Antibody (C-7) is a mouse monoclonal IgG2a antibody that detects RXRα in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RXRα, a member of the retinoid X receptor family, plays a crucial role in mediating the effects of retinoic acid, which is vital for various biological processes including cell differentiation, growth, and apoptosis. This receptor is predominantly located in the nucleus, where RXRα functions as a transcription factor that regulates gene expression in response to retinoid signaling. The nuclear localization of RXRα is essential because RXRα interacts with specific DNA sequences and forms heterodimers with other nuclear receptors, such as retinoic acid receptors (RARs), thereby amplifying the regulatory effects on target genes. Anti-RXRα antibody (C-7) provides reliable detection and characterization of RXRα, facilitating research into RXRα′s role in development and disease, particularly in cancer and metabolic disorders.
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RXRα Antibody (C-7) References:
- Targeting truncated RXRα for cancer therapy. | Zhang, X., et al. 2016. Acta Biochim Biophys Sin (Shanghai). 48: 49-59. PMID: 26494413
- Overview of the structure-based non-genomic effects of the nuclear receptor RXRα. | Chen, L., et al. 2018. Cell Mol Biol Lett. 23: 36. PMID: 30093910
- RXRα Regulates the Development of Resident Tissue Macrophages. | Philpott, J., et al. 2022. Immunohorizons. 6: 366-372. PMID: 35732333
- Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation. | Zhang, HF., et al. 2023. Acta Pharmacol Sin. 44: 1051-1065. PMID: 36347997
- Molecular basis of ligand-dependent Nurr1-RXRα activation. | Yu, X., et al. 2023. Elife. 12: PMID: 37102494
- Stationary-to-migratory transition in glioblastoma stem-like cells driven by a fatty acid-binding protein 7-RXRα neurogenic pathway. | Liu, RZ., et al. 2023. Neuro Oncol. 25: 2177-2190. PMID: 37499046
- ZNF148 inhibits HBV replication by downregulating RXRα transcription. | Yao, X., et al. 2024. Virol J. 21: 35. PMID: 38297280
- Activation of RXRα exerts cardioprotection through transcriptional upregulation of Ndufs4 in heart failure. | Shao, M., et al. 2024. Sci Bull (Beijing). 69: 1202-1207. PMID: 38310046
- Molecular regulation of PPARγ/RXRα signaling by the novel cofactor ZFP407. | Charrier, A., et al. 2024. PLoS One. 19: e0294003. PMID: 38781157
- RXRα/MR signaling promotes diabetic kidney disease by facilitating renal tubular epithelial cells senescence and metabolic reprogramming. | Feng, Q., et al. 2024. Transl Res. 274: 101-117. PMID: 39424127
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RXRα Antibody (C-7) | sc-515928 | 200 µg/ml | $322.00 | |||
RXRα Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-541091 | 200 µg Ab; 10 µg BP | $361.00 | |||
RXRα Antibody (C-7) X | sc-515928 X | 200 µg/0.1 ml | $322.00 |