RUNDC3A Antibody (H-9): sc-390248
- RUNDC3A Antibody (H-9) is a mouse monoclonal IgG2a κ RUNDC3A antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 145-177 within an internal region of RUNDC3A of human origin
- RUNDC3A Antibody (H-9) is recommended for detection of RUNDC3A of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-RUNDC3A Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for RUNDC3A Antibody (H-9) for WB applications. These reagents are now offered in bundles with RUNDC3A Antibody (H-9) (see ordering information below).
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RUNDC3A Antibody (H-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects RUNDC3A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-RUNDC3A antibody (H-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RUNDC3A, also known as RPIP-8 or RAP2IP, is a 446 amino acid protein that plays a crucial role as an effector protein of RAP2A in neuronal cells, influencing cellular signaling pathways vital for neuronal function and development. RUNDC3A is a member of the RUNDC3 family and features a RUN domain, with alternative splicing giving rise to four distinct isoforms. RUNDC3A is predominantly expressed in the testis, brain, kidney, and liver, and is encoded by a gene located on human chromosome 17q21.31, a region that harbors over 1,200 genes, including key tumor suppressor genes such as p53 and BRCA1. p53 is essential for maintaining cellular genetic integrity, regulating cell fate decisions between DNA repair and apoptosis, while BRCA1 is recognized for its role in DNA repair and association with early-onset breast cancer and other malignancies. Research on RUNDC3A and its interactions is important for understanding potential implications in neurobiology and cancer research, making RUNDC3A (H-9) antibody a valuable tool for researchers in these fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RUNDC3A Antibody (H-9) References:
- p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis. | Soussi, T., et al. 2000. Hum Mutat. 15: 105-13. PMID: 10612830
- Distinct pattern of p53 phosphorylation in human tumors. | Minamoto, T., et al. 2001. Oncogene. 20: 3341-7. PMID: 11423984
- Three primary malignancies related to BRCA mutation successively occurring in a BRCA1 185delAG mutation carrier. | Piura, B., et al. 2001. Eur J Obstet Gynecol Reprod Biol. 97: 241-4. PMID: 11451557
- Closing in on a breast cancer gene on chromosome 17q. | Hall, JM., et al. 1992. Am J Hum Genet. 50: 1235-42. PMID: 1598904
- A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene. | Varley, JM., et al. 1997. Oncogene. 14: 865-71. PMID: 9047394
- The Li-Fraumeni syndrome: an inherited susceptibility to cancer. | Evans, SC. and Lozano, G. 1997. Mol Med Today. 3: 390-5. PMID: 9302689
- Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix. | Kersemaekers, AM., et al. 1998. Br J Cancer. 77: 192-200. PMID: 9460988
- Identification of a specific effector of the small GTP-binding protein Rap2. | Janoueix-Lerosey, I., et al. 1998. Eur J Biochem. 252: 290-8. PMID: 9523700
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RUNDC3A Antibody (H-9) | sc-390248 | 200 µg/ml | $316.00 | |||
RUNDC3A Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-526138 | 200 µg Ab; 10 µg BP | $354.00 | |||
RUNDC3A Antibody (H-9): m-IgG2a BP-HRP Bundle | sc-546512 | 200 µg Ab; 10 µg BP | $354.00 | |||
RUNDC3A Antibody (H-9) AC | sc-390248 AC | 500 µg/ml, 25% agarose | $416.00 | |||
RUNDC3A Antibody (H-9) HRP | sc-390248 HRP | 200 µg/ml | $316.00 | |||
RUNDC3A Antibody (H-9) FITC | sc-390248 FITC | 200 µg/ml | $330.00 | |||
RUNDC3A Antibody (H-9) PE | sc-390248 PE | 200 µg/ml | $343.00 | |||
RUNDC3A Antibody (H-9) Alexa Fluor® 488 | sc-390248 AF488 | 200 µg/ml | $357.00 | |||
RUNDC3A Antibody (H-9) Alexa Fluor® 546 | sc-390248 AF546 | 200 µg/ml | $357.00 | |||
RUNDC3A Antibody (H-9) Alexa Fluor® 594 | sc-390248 AF594 | 200 µg/ml | $357.00 | |||
RUNDC3A Antibody (H-9) Alexa Fluor® 647 | sc-390248 AF647 | 200 µg/ml | $357.00 | |||
RUNDC3A Antibody (H-9) Alexa Fluor® 680 | sc-390248 AF680 | 200 µg/ml | $357.00 | |||
RUNDC3A Antibody (H-9) Alexa Fluor® 790 | sc-390248 AF790 | 200 µg/ml | $357.00 | |||
RUNDC3A (H-9) Neutralizing Peptide | sc-390248 P | 100 µg/0.5 ml | $68.00 |