Rtn-1/2 Antibody (RNL-2): sc-23881
- Rtn-1/2 Antibody (RNL-2) is a mouse monoclonal IgG1 κ Rtn-1/2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against the small cell lung cancer cell line NCI-H82
- Rtn-1/2 Antibody (RNL-2) is recommended for detection of Rtn-1 and Rtn-2 of human, rabbit and Rhesus monkey origin by WB, IP and IF
- Anti-Rtn-1/2 Antibody (RNL-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Rtn-1/2 Antibody (RNL-2) for WB applications. These reagents are now offered in bundles with Rtn-1/2 Antibody (RNL-2) (see ordering information below).
Rtn-1/2 Antibody (RNL-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rtn-1/2 protein of human, rabbit, and Rhesus monkey origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Rtn-1/2 antibody (RNL-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The reticulon (Rtn) family, which includes Rtn-1, Rtn-2, Rtn-3, and Nogo, plays a crucial role in the endoplasmic reticulum′s structure and function, particularly in neural and neuroendocrine tissues. Rtn-1, also known as neuroendocrine-specific protein, is essential for maintaining endoplasmic reticulum integrity and is involved in neuroendocrine secretion and membrane trafficking. Rtn-1′s structure, characterized by its reticulon homology domain, is vital for shaping the endoplasmic reticulum and facilitating membrane tubule formation. Rtn-2, encoded by a gene located on chromosome 19q13, also contributes to these processes and is expressed in various tissues, with Rtn-2-A and Rtn-2-B isoforms being highly abundant in the brain. Understanding Rtn proteins′ structure and function helps elucidate their roles in cellular processes and potential implications in neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rtn-1/2 Antibody (RNL-2) References:
- Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. | Moreira, EF., et al. 1999. Genomics. 58: 73-81. PMID: 10331947
- Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. | GrandPré, T., et al. 2000. Nature. 403: 439-44. PMID: 10667797
- Nspl1, a new Z-band-associated protein. | Geisler, JG., et al. 1999. J Muscle Res Cell Motil. 20: 661-8. PMID: 10672514
- Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4. | Ikemoto, T., et al. 2009. Diabetes. 58: 2802-12. PMID: 19720795
- Involvement of a phosphorylation-mediated pathway to regulate the function of NSPL1 in exercise. | Ikemoto, T., et al. 2011. J Vet Med Sci. 73: 733-8. PMID: 21258182
- Subcellular localization and supramolecular organization of neuroendocrine-specific protein B (NSP-B) in small cell lung cancer. | Senden, NH., et al. 1994. Eur J Cell Biol. 65: 341-53. PMID: 7720728
- NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis. | van de Velde, HJ., et al. 1994. Cancer Res. 54: 4769-76. PMID: 8062278
- Stromal keratitis induced by a unique clinical isolate of herpes simplex virus type 1. | Sakai, Y., et al. 1994. Ophthalmologica. 208: 157-60. PMID: 8065701
- Pathogenicity of glycoprotein C-deficient herpes simplex virus 1 strain TN-1 which encodes truncated glycoprotein C. | Minagawa, H., et al. 1997. Microbiol Immunol. 41: 545-51. PMID: 9272700
- Molecular cloning of a novel mouse gene with predominant muscle and neural expression. | Geisler, JG., et al. 1998. Mamm Genome. 9: 274-82. PMID: 9530622
- Neuronal differentiation is accompanied by NSP-C expression. | Hens, J., et al. 1998. Cell Tissue Res. 292: 229-37. PMID: 9560466
- cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons. | Roebroek, AJ., et al. 1998. Genomics. 51: 98-106. PMID: 9693037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rtn-1/2 Antibody (RNL-2) | sc-23881 | 200 µg/ml | $316.00 | |||
Rtn-1/2 Antibody (RNL-2): m-IgG Fc BP-HRP Bundle | sc-526625 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rtn-1/2 Antibody (RNL-2): m-IgG1 BP-HRP Bundle | sc-531998 | 200 µg Ab; 20 µg BP | $354.00 | |||
Rtn-1/2 Antibody (RNL-2) AC | sc-23881 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Rtn-1/2 Antibody (RNL-2) HRP | sc-23881 HRP | 200 µg/ml | $316.00 | |||
Rtn-1/2 Antibody (RNL-2) FITC | sc-23881 FITC | 200 µg/ml | $330.00 | |||
Rtn-1/2 Antibody (RNL-2) PE | sc-23881 PE | 200 µg/ml | $343.00 | |||
Rtn-1/2 Antibody (RNL-2) Alexa Fluor® 488 | sc-23881 AF488 | 200 µg/ml | $357.00 | |||
Rtn-1/2 Antibody (RNL-2) Alexa Fluor® 546 | sc-23881 AF546 | 200 µg/ml | $357.00 | |||
Rtn-1/2 Antibody (RNL-2) Alexa Fluor® 594 | sc-23881 AF594 | 200 µg/ml | $357.00 | |||
Rtn-1/2 Antibody (RNL-2) Alexa Fluor® 647 | sc-23881 AF647 | 200 µg/ml | $357.00 | |||
Rtn-1/2 Antibody (RNL-2) Alexa Fluor® 680 | sc-23881 AF680 | 200 µg/ml | $357.00 | |||
Rtn-1/2 Antibody (RNL-2) Alexa Fluor® 790 | sc-23881 AF790 | 200 µg/ml | $357.00 |