RT1-Ac Antibody (6A444): sc-71976

RT1-Ac Antibody (6A444) is a mouse monoclonal IgG2a antibody that detects RT1-Ac in mouse and rat samples through immunofluorescence (IF) and flow cytometry (FCM) applications. RT1-Ac is a crucial component of the rat class I major histocompatibility complex (MHC I) molecules, specifically representing haplotype c of the RT1-A antigens. Anti-RT1-Ac antibody (6A444) recognizes molecules that play a vital role in the immune response by presenting nonself peptides on the cell surface, which are essential for recognition by cytotoxic T-lymphocytes (CTLs). The structure of RT1-Ac consists of two polypeptide chains: an alpha or heavy chain and beta-2-microglobulin, a non-covalently associated protein. This structural arrangement allows for the binding of antigenic peptides, typically 8-10 residues in length, within a specialized peptide binding groove, thereby stabilizing the interaction and facilitating effective immune surveillance. RT1-Ac′s ability to present these peptides is critical for the activation of CTLs, which are essential for targeting and eliminating infected or malignant cells. RT1-Ac monoclonal antibody (6A444) serves as an invaluable tool for researchers studying immune responses in rodent models.

The preferred RT1-Ac antibody is RT1-Ac Antibody (OX27): sc-53076.