Date published: 2026-4-5

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(RS)-Atenolol (CAS 29122-68-7)

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Alternate Names:
2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
Application:
(RS)-Atenolol is an inhibitor of β1-AR and β2-AR
CAS Number:
29122-68-7
Purity:
≥97%
Molecular Weight:
266.34
Molecular Formula:
C14H22N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(RS)-Atenolol is a beta-adrenergic antagonist that functions by competitively blocking beta-adrenergic receptors in the heart and peripheral vasculature. (RS)-Atenolol inhibits the action of catecholamines, such as adrenaline, on the beta receptors, leading to a decrease in heart rate and cardiac output. By blocking these receptors, (RS)-Atenolol reduces the stimulation of the heart and decreases the workload on the heart, making it useful in studies investigating the effects of beta-adrenergic signaling on cardiovascular function. At the molecular level, (RS)-Atenolol binds to the beta-adrenergic receptors, preventing the activation of G-proteins and subsequent intracellular signaling pathways. This interference with beta-adrenergic signaling can be useful in elucidating the role of these receptors in various physiological processes.


(RS)-Atenolol (CAS 29122-68-7) References

  1. Liquid chromatographic enantioseparation of three beta-adrenolytics using new derivatizing reagents synthesized from (S)-ketoprofen and confirmation of configuration of diastereomers.  |  Alwera, S. and Bhushan, R. 2016. Biomed Chromatogr. 30: 1772-1781. PMID: 27129403
  2. Bioassay, determination and separation of enantiomers of atenolol by direct and indirect approaches using liquid chromatography: A review.  |  Batra, S. and Bhushan, R. 2018. Biomed Chromatogr. 32: PMID: 28905405
  3. Enhancement of arterial relaxation by long-term atenolol treatment in spontaneously hypertensive rats.  |  Kähönen, M., et al. 1994. Br J Pharmacol. 112: 925-33. PMID: 7921622
  4. Stereoselective pharmacokinetics of atenolol in the rat: influence of aging and of renal failure.  |  Belpaire, FM., et al. 1993. Mech Ageing Dev. 67: 201-10. PMID: 8469031
  5. Racemic Compound, Conglomerate, or Solid Solution: Phase Diagram Screening of Chiral Compounds  |  Cryst. Growth Des. 2010. Cryst. Growth Des. 10: 1808–1812.
  6. (S)-Naproxen based novel chiral reagent for C–N bond formation: enantioseparation of some β-blockers, determination of absolute configuration and elution order of diastereomers  |  Manisha Singh and Ravi Bhushan*. 2015. RSC Adv. 5: 70255-70264.
  7. Enantioseparation of (RS)-atenolol with the use of lipases immobilized onto new-synthesized magnetic nanoparticles  |  Adam Sikora a, Dorota Chełminiak-Dudkiewicz b, Marta Ziegler-Borowska b, Michał Piotr Marszałł a. 2017. Tetrahedron: Asymmetry. 28: 374-380.
  8. Crystallization of R-(+)-atenolol hydrochloride from racemic ionic liquid - A selective double decomposition green reaction  |  Rama Kumar Kandula a, Suresh B. Vepuri b, H.C. Devarajegowda c, S. Raja a. 2018. Journal of Molecular Structure. 1169: 39-45.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(RS)-Atenolol, 1 g

sc-204895
1 g
$79.00

(RS)-Atenolol, 10 g

sc-204895A
10 g
$416.00