(RS)-α-Methyl-3-carboxy-4-hydroxyphenylglycine
Application:
(RS)-α-Methyl-3-carboxy-4-hydroxyphenylglycine is a group I/group II mGluR antagonist
Molecular Weight:
225.2
Molecular Formula:
C10H11NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(RS)-α-Methyl-3-carboxy-4-hydroxyphenylglycine is a potent antagonist of both L-AP4 and L-CCG-I-induced depressions of forskolin-stimulated cAMP production. It shows preferential antagonist activity versus L-CCG-I. Group I/group II mGluR antagonist at cloned receptors.
(RS)-α-Methyl-3-carboxy-4-hydroxyphenylglycine References
- Pharmacological agents acting at subtypes of metabotropic glutamate receptors. | Schoepp, DD., et al. 1999. Neuropharmacology. 38: 1431-76. PMID: 10530808
- Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. | Watkins, J. and Collingridge, G. 1994. Trends Pharmacol Sci. 15: 333-42. PMID: 7992387
- Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). | Bedingfield, JS., et al. 1995. Br J Pharmacol. 116: 3323-9. PMID: 8719814
- Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. | Sekiyama, N., et al. 1996. Br J Pharmacol. 117: 1493-503. PMID: 8730745
Inhibitor of:
mGluR, mGluR-1a, mGluR-1b, mGluR-2, mGluR-3, and mGluR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(RS)-α-Methyl-3-carboxy-4-hydroxyphenylglycine, 5 mg | sc-222264 | 5 mg | $60.00 |