RREB1 Antibody (B-7): sc-515600

RREB1 Antibody (B-7) is a mouse monoclonal IgM antibody that detects RREB1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RREB1 antibody (B-7) is available as the non-conjugated form. RREB1, also known as ras responsive element binding protein 1, FINB, LZ321, or Zep-1, is a 1,687 amino acid protein that plays a crucial role in cellular processes by localizing to nuclear speckles and containing fifteen C2H2-type zinc fingers. RREB1 functions primarily as a transcription factor, binding to the RAS-responsive element (RRE) of target gene promoters to induce their transcription, which is vital for regulating genes involved in cell growth and differentiation. RREB1 is expressed in various tissues, including the pancreas, heart, liver, placenta, lung, kidney, and skeletal muscle, and is involved in Raf/Ras-mediated cell differentiation, particularly by enhancing Calcitonin expression, a hormone essential for maintaining blood calcium levels. RREB1 is important not only for normal cellular differentiation but also for potential implications in Raf/Ras-related tumor formation, making RREB1 significant in cancer research. Additionally, four isoforms of RREB1 exist due to alternative splicing, which may contribute to diverse regulatory roles in different cellular contexts.

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RREB1 Antibody (B-7) References:

1. A human Raf-responsive zinc-finger protein that binds to divergent sequences.  |  Zhang, L., et al. 1999. Nucleic Acids Res. 27: 2947-56. PMID: 10390538
2. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1.  |  Ray, SK., et al. 2003. Mol Cell Biol. 23: 259-71. PMID: 12482979
3. p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.  |  Zhang, S., et al. 2003. Oncogene. 22: 2285-95. PMID: 12700664
4. Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene.  |  Date, S., et al. 2004. Int J Mol Med. 13: 637-42. PMID: 15067362
5. Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1.  |  Melani, M., et al. 2008. Curr Biol. 18: 532-7. PMID: 18394891
6. Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation.  |  Carson, EB., et al. 1995. Cancer Res. 55: 2048-52. PMID: 7743500
7. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas.  |  Thiagalingam, A., et al. 1996. Mol Cell Biol. 16: 5335-45. PMID: 8816445
8. A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies.  |  Fujimoto-Nishiyama, A., et al. 1997. Gene. 195: 267-75. PMID: 9305772
9. RREB1, a ras responsive element binding protein, maps to human chromosome 6p25.  |  Thiagalingam, A., et al. 1997. Genomics. 45: 630-2. PMID: 9367691

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RREB1 Antibody (B-7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-RREB1 Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RREB1 Antibody (B-7) Specifications

Alternate Product Name: RREB1

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 302-319

Epitope Target: RREB1

Epitope Species: human

Product Reactivity/Detection: RREB1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for RREB1 Antibody (B-7): P: Blocking Peptide