RPTPα Antibody (D-11): sc-133069

RPTPα Antibody (D-11) is a mouse monoclonal IgG1 antibody that detects receptor protein-tyrosine phosphatase α (RPTPα) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RPTPα plays a crucial role in cellular signaling by dephosphorylating and activating Src family tyrosine kinases, which are essential for regulating integrin signaling, cell adhesion, and growth factor responsiveness. RPTPα is located in the cell membrane, where RPTPα contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, allowing RPTPα to form constitutive dimers that enhance functional capacity. The human RPTPα sequence encodes a 793 amino acid protein, and RPTPα phosphorylation at Ser 180 and Ser 204 is critical for activity, particularly in signaling pathways that influence cell growth and migration. Additionally, RPTPα serves as a receptor for the Helicobacter pylori vacuolating cytotoxin, VacA, highlighting RPTPα importance in both normal cellular functions and pathogenic processes. Anti-RPTPα antibody (D-11) is an invaluable tool for researchers studying these complex signaling mechanisms and their implications in health and disease.

The preferred RPTPα antibody is RPTPα Antibody (H-4): sc-398203.