Rpp30 Antibody (2931D5a): sc-81374

Rpp30 Antibody (2931D5a) is a mouse monoclonal IgG1 antibody that detects Rpp30 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Rpp30 antibody (2931D5a) is available as the non-conjugated format. Rpp30, a crucial component of the ribonuclease P complex, plays a vital role in RNA processing, specifically in the maturation of precursor tRNA molecules. By catalyzing the hydrolysis of a specific phosphodiester bond, Rpp30 facilitates the removal of 5′ leader sequences, which is essential for generating functional tRNA necessary for protein synthesis. Proper functioning of Rpp30 is critical, as defects in this process can lead to various cellular dysfunctions and contribute to diseases. Additionally, Rpp30 is localized in the nucleolus, where Rpp30 accumulates alongside other ribonucleoproteins, highlighting its importance in the cellular machinery responsible for RNA metabolism. The association of Rpp30 with Th/To ribonucleoproteins has also led to its identification as an autoantigen in systemic sclerosis, underscoring its relevance in autoimmune conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Rpp30 Antibody (2931D5a) References:

1. RNA-protein interactions in the human RNase MRP ribonucleoprotein complex.  |  Pluk, H., et al. 1999. RNA. 5: 512-24. PMID: 10199568
2. Architecture and function of the human endonucleases RNase P and RNase MRP.  |  van Eenennaam, H., et al. 2000. IUBMB Life. 49: 265-72. PMID: 10995027
3. Ribonuclease P: a ribonucleoprotein enzyme.  |  Kurz, JC. and Fierke, CA. 2000. Curr Opin Chem Biol. 4: 553-8. PMID: 11006544
4. The road to RNase P.  |  Altman, S. 2000. Nat Struct Biol. 7: 827-8. PMID: 11017184
5. Basic domains target protein subunits of the RNase MRP complex to the nucleolus independently of complex association.  |  van Eenennaam, H., et al. 2001. Mol Biol Cell. 12: 3680-9. PMID: 11694598
6. RNase MRP/RNase P: a structure-function relation conserved in evolution?  |  Karwan, R. 1993. FEBS Lett. 319: 1-4. PMID: 7681014
7. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.  |  Jarrous, N., et al. 1998. RNA. 4: 407-17. PMID: 9630247

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rpp30 Antibody (2931D5a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Rpp30 Antibody (2931D5a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rpp30 Antibody (2931D5a) Specifications

Alternate Product Name: Rpp30

Product Clone Name: 2931D5a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Rpp30

Epitope Species: human

Product Reactivity/Detection: Rpp30

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Rpp30 Antibody (2931D5a): N/A