RPGRIP1 Antibody (B-3): sc-390331

RPGRIP1 Antibody (B-3) is a mouse monoclonal IgG3 antibody that detects RPGRIP1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RPGRIP1, also known as retinitis pigmentosa GTPase regulator interacting protein 1, is a crucial 1,286 amino acid protein that plays a significant role in photoreceptor structure and function in the retina. RPGRIP1 is primarily localized to the cilium, where anti-RPGRIP1 antibody (B-3) has shown essential functions in proper morphogenesis of photoreceptor disks, a process vital for maintaining photoreceptor integrity and function. RPGRIP1 forms homodimers and elongated homopolymers, and exists in six alternatively spliced isoforms, which may contribute to diverse functional roles in retinal health. RPGRIP1 monoclonal antibody (B-3) has demonstrated interaction with SEC16S, a protein necessary for trafficking proteins to the cilium, highlighting critical involvement in cellular processes that ensure photoreceptor survival. Mutations in RPGRIP1 are linked to severe retinal diseases, including Leber congenital amaurosis type 6 and cone-rod dystrophy type 13, making RPGRIP1 (B-3) antibody an invaluable tool for studying these conditions and understanding underlying mechanisms of retinal degeneration.

The preferred RPGRIP1 antibody is RPGRIP1 Antibody (C-9): sc-390341.