ROS-GC1 Antibody (A-5): sc-514879

ROS-GC1 Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects ROS-GC1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ROS-GC1, a member of the guanylate cyclase family, plays a pivotal role in the phototransduction pathway, which is essential for converting light signals into visual information. ROS-GC1 is primarily located in the nuclei and inner segments of rod and cone photoreceptor cells in the retina, where ROS-GC1 facilitates the regulation of intracellular levels of cyclic guanosine monophosphate (cGMP), a crucial second messenger in visual signaling. The proper functioning of ROS-GC1 is vital for maintaining photoreceptor health and function; any defects in the GUCY2D gene that encodes ROS-GC1 can lead to severe visual impairments, such as those seen in dominant cone-rod dystrophy type 6 (CORD6). CORD6 is characterized by the early degeneration of cone photoreceptors, resulting in a loss of visual acuity and color vision, followed by the progressive degeneration of rod photoreceptors, which leads to night blindness and peripheral vision loss. Anti-ROS-GC1 antibody (A-5) is an invaluable tool for researchers studying the molecular mechanisms underlying phototransduction and related retinal diseases.

The preferred ROS-GC1 antibody is ROS-GC1 Antibody (B-7): sc-376217.