ROPN1 Antibody (IW.63): sc-130455

ROPN1 Antibody (IW.63) is a mouse monoclonal IgG2a kappa light chain antibody that detects ROPN1 protein of human origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ROPN1 antibody (IW.63) is available as a non-conjugated format. ROPN1, also known as Ropporin, plays a crucial role in regulating sperm motility and function through interactions with other proteins in sperm flagella. ROPN1 is localized specifically in testis and fetal liver under normal physiological conditions, with expression observed in various hematological malignancies, including multiple myeloma, chronic lymphocytic leukemia, and acute myeloid leukemia. ROPN1 forms complexes with rhophilin, essential for mediating signaling pathways that govern sperm function. ROPN1 serves as an anchoring protein for A-kinase anchoring proteins (AKAP), such as AKAP 3, vital for protein kinase A (PKA) signaling compartmentalization within cells. This compartmentalization ensures PKA effects at specific cellular locations, influencing various cellular processes. ROPN1′s unique expression pattern and protein interactions make ROPN1 a significant marker for studying reproductive biology and certain cancers, highlighting potential therapeutic intervention targets.

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ROPN1 Antibody (IW.63) References:

1. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella.  |  Fujita, A., et al. 2000. J Cell Sci. 113 (Pt 1): 103-12. PMID: 10591629
2. Fibrous sheath of mammalian spermatozoa.  |  Eddy, EM., et al. 2003. Microsc Res Tech. 61: 103-15. PMID: 12672126
3. A yeast two-hybrid system using Sp17 identified Ropporin as a novel cancer-testis antigen in hematologic malignancies.  |  Li, Z., et al. 2007. Int J Cancer. 121: 1507-11. PMID: 17551920
4. Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction.  |  Newell, AE., et al. 2008. Cell Motil Cytoskeleton. 65: 539-52. PMID: 18421703
5. Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinase.  |  Scott, JD., et al. 1990. J Biol Chem. 265: 21561-6. PMID: 2147685
6. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein.  |  Coghlan, VM., et al. 1995. Science. 267: 108-11. PMID: 7528941
7. A-kinase anchoring proteins: a key to selective activation of cAMP-responsive events?  |  Coghlan, VM., et al. 1993. Mol Cell Biochem. 127-128: 309-19. PMID: 7935359

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ROPN1 Antibody (IW.63) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ROPN1 Antibody (IW.63) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ROPN1 Antibody (IW.63) Specifications

Alternate Product Name: ROPN1

Product Clone Name: IW.63

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-120

Epitope Target: ROPN1

Epitope Species: human

Product Reactivity/Detection: ROPN1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ROPN1 Antibody (IW.63): N/A