Ron β Antibody (E-9): sc-374626
- Ron β Antibody (E-9) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1371-1400 at the C-terminus of Ron β of human origin
- Anti-Ron beta Antibody (E-9) is recommended for detection of Ron β of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Ron beta Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Ron β Antibody (E-9) for WB applications. These reagents are now offered in bundles with Ron β Antibody (E-9) (see ordering information below).
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Ron β Antibody (E-9) is a mouse monoclonal IgG2a kappa light chain antibody designed to recognize an epitope mapping between amino acids 1371-1400 at the C-terminus of the human Ron β protein, also known as MST1R, macrophage-stimulating protein receptor (MSP receptor), p185-Ron, CD136 antigen, or PTK8. Ron β is the intracellular domain of the Ron receptor tyrosine kinase, which plays a critical role in cellular signaling pathways that regulate processes such as growth, survival, and migration. Post-translational modifications of Ron β, including phosphorylation, are essential for its activation and function, enabling the recruitment of downstream signaling molecules and the propagation of signal transduction cascades. These modifications are crucial for maintaining normal cellular homeostasis and are often dysregulated in various cancers, making Ron β a significant target for therapeutic intervention and cancer research. Ron β (E-9) monoclonal antibody exhibits broad species reactivity, effectively recognizing Ron β from mouse, rat, and human origins in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), ensuring versatile utility across different experimental setups. By specifically targeting a conserved epitope within the C-terminal region, anti-Ron β antibody (E-9) provides reliable detection and quantification of Ron β expression and its post-translational modifications, facilitating detailed studies of Ron-mediated signaling pathways. Ron β (E-9) monoclonal antibody ensures consistent and accurate results, enabling researchers to explore the mechanisms underlying Ron β function and its role in disease progression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ron β Antibody (E-9) References:
- Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. | Rong, S., et al. 1992. Mol Cell Biol. 12: 5152-8. PMID: 1406687
- Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. | Bottaro, DP., et al. 1991. Science. 251: 802-4. PMID: 1846706
- Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts. | Cooper, CS., et al. 1986. EMBO J. 5: 2623-8. PMID: 3023053
- p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line. | Giordano, S., et al. 1988. Mol Cell Biol. 8: 3510-7. PMID: 3211149
- Identification of the ron gene product as the receptor for the human macrophage stimulating protein. | Wang, MH., et al. 1994. Science. 266: 117-9. PMID: 7939629
- RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. | Gaudino, G., et al. 1994. EMBO J. 13: 3524-32. PMID: 8062829
- A novel putative receptor protein tyrosine kinase of the met family. | Ronsin, C., et al. 1993. Oncogene. 8: 1195-202. PMID: 8386824
- Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain. | Wang, MH., et al. 1997. J Biol Chem. 272: 16999-7004. PMID: 9202013
- Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development. | Pawson, T. and Bernstein, A. 1990. Trends Genet. 6: 350-6. PMID: 1965067
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ron β Antibody (E-9) | sc-374626 | 200 µg/ml | $322.00 | |||
Ron β Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-525981 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ron β Antibody (E-9): m-IgG2a BP-HRP Bundle | sc-546475 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ron β Antibody (E-9) AC | sc-374626 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Ron β Antibody (E-9) HRP | sc-374626 HRP | 200 µg/ml | $322.00 | |||
Ron β Antibody (E-9) FITC | sc-374626 FITC | 200 µg/ml | $336.00 | |||
Ron β Antibody (E-9) PE | sc-374626 PE | 200 µg/ml | $349.00 | |||
Ron β Antibody (E-9) Alexa Fluor® 488 | sc-374626 AF488 | 200 µg/ml | $364.00 | |||
Ron β Antibody (E-9) Alexa Fluor® 546 | sc-374626 AF546 | 200 µg/ml | $364.00 | |||
Ron β Antibody (E-9) Alexa Fluor® 594 | sc-374626 AF594 | 200 µg/ml | $364.00 | |||
Ron β Antibody (E-9) Alexa Fluor® 647 | sc-374626 AF647 | 200 µg/ml | $364.00 | |||
Ron β Antibody (E-9) Alexa Fluor® 680 | sc-374626 AF680 | 200 µg/ml | $364.00 | |||
Ron β Antibody (E-9) Alexa Fluor® 790 | sc-374626 AF790 | 200 µg/ml | $364.00 | |||
Ron β (E-9) Neutralizing Peptide | sc-374626 P | 100 µg/0.5 ml | $69.00 |