Ro 27-3225 trifluoroacetate salt Ro 27-3225 trifluoroacetate salt is a selective melanocortin MC4 receptor agonist.

Ro 27-3225 trifluoroacetate salt

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Alternate Names: Butir-His-D-Phe-Arg-Trp-Sar-NH2 trifluoroacetate salt
Application: Ro 27-3225 trifluoroacetate salt is a selective melanocortin MC4 receptor agonist
Purity: ≥97%
Molecular Weight: 784.91 (free base basis)
Molecular Formula: C39H52N12O6•xC2HF3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Ro 27-3225 trifluoroacetate salt is a selective MC4-R (melanocortin MC4 receptor) agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor and can reverse hemorrhagic shock, reduces multiple organ damage, and improves survival. This can have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.


References

1. Giuliani, D. 2007. Br. J. Pharmacol. 150(5): 595-603. PMID: 17245369 2. Benoit, S.C. 2000. J. Neurosci. 20(9): 3442-3448. PMID: 10777807

Appearance :
Lyophilized
Physical State :
Solid
Solubility :
Soluble in water (>10 mg/ml).
Storage :
Store at room temperature
Refractive Index :
n20D 1.67 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9962372
MDL Number :
MFCD04112656
SMILES :
CCCC(=O)N[[email protected]@H](CC1=CN=CN1)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)N[[email protected]@H](CCCN=C(N)N)C(=O)N[[email protected]@H](CC3=CNC4=CC=CC=C43)C(=O)N(C)CC(=O)N

Download SDS (MSDS)

Certificate of Analysis

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该药半衰期是多少

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