RNMTL1 Antibody (F-3): sc-374210

RNMTL1 Antibody (F-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects RNMTL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RNMTL1 (F-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RNMTL1, also known as RNA methyltransferase like 1 or HC90, is a 420 amino acid protein that belongs to the RNA methyltransferase trmH family, which is crucial for the transfer of methyl groups to RNA molecules. This post-translational modification influences RNA stability, splicing, and translation, thereby playing a significant role in regulating gene expression and cellular signaling pathways. RNMTL1 is predominantly expressed in normal liver tissue and hepatocarcinoma, highlighting potential involvement in cancer biology. The gene encoding RNMTL1 is located on human chromosome 17, a region that is home to several important tumor suppressor genes, including p53 and BRCA1, both essential for maintaining genomic integrity and preventing tumorigenesis. RNMTL1′s interaction with these tumor suppressors may provide insights into cancer development and progression, making anti-RNMTL1 antibody (F-3) a valuable tool for researchers studying RNA modifications and their implications in health and disease.

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RNMTL1 Antibody (F-3) References:

1. The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene.  |  Xu, J., et al. 2002. Cell Res. 12: 177-97. PMID: 12296377
2. [Expression of novel cloned genes HC56, HC71 and HC90 mapped on human chromosome 17p13.3 in leukemic cells].  |  Wang, R., et al. 2002. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 10: 419-22. PMID: 12513740
3. New enzymes from environmental cassette arrays: functional attributes of a phosphotransferase and an RNA-methyltransferase.  |  Nield, BS., et al. 2004. Protein Sci. 13: 1651-9. PMID: 15152095
4. Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family.  |  Watanabe, K., et al. 2005. J Biol Chem. 280: 10368-77. PMID: 15637073
5. Identification and characterization of RsmE, the founding member of a new RNA base methyltransferase family.  |  Basturea, GN., et al. 2006. RNA. 12: 426-34. PMID: 16431987
6. Neurofibromatosis 1, and Not TP53, seems to be the main target of chromosome 17 deletions in de novo acute myeloid leukemia.  |  Suela, J., et al. 2007. J Clin Oncol. 25: 1151-2; author reply 1152-3. PMID: 17369586
7. Structural organization of box C/D RNA-guided RNA methyltransferase.  |  Ye, K., et al. 2009. Proc Natl Acad Sci U S A. 106: 13808-13. PMID: 19666563
8. Site specificities of three transfer RNA methyltransferases from yeast.  |  Sindhuphak, T., et al. 1985. Biochim Biophys Acta. 824: 66-73. PMID: 3881130
9. Susceptibility to breast cancer: hereditary syndromes and low penetrance genes.  |  Nusbaum, R., et al. Breast Dis. 27: 21-50. PMID: 17917139

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RNMTL1 Antibody (F-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-RNMTL1 Antibody (F-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RNMTL1 Antibody (F-3) Specifications

Alternate Product Name: RNMTL1

Product Clone Name: F-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 205-239

Epitope Target: RNMTL1

Epitope Species: human

Product Reactivity/Detection: RNMTL1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for RNMTL1 Antibody (F-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin