RNF40 Antibody (1C1): sc-293333
- RNF40 Antibody (1C1) is a mouse monoclonal IgG2a κ RNF40 antibody provided at 100 µg/ml
- raised against amino acids 102-200 of RNF40 of human origin
- recommended for detection of RNF40 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RNF40 Antibody (1C1). This work is in progress.
RNF40 Antibody (1C1) is a mouse monoclonal IgG2a kappa light chain antibody that detects the RNF40 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-RNF40 antibody (1C1) is available as the non-conjugated format. RNF40, also known as RING finger protein 40, BRE1B, Staring, or RBP95, is a crucial nuclear protein composed of 1,001 amino acids and characterized by a single RING-type zinc finger domain. RNF40 is predominantly expressed in the heart, testis, and pancreas, where RNF40 plays a vital role as an E3 ubiquitin-protein ligase, facilitating the monoubiquitination and subsequent degradation of specific target proteins, including Histone H2B and Syntaxin 1. RNF40′s importance lies in regulating the histone code through interaction with UBCH6, an E2 enzyme, forming a ubiquitin ligase complex that is essential for maintaining cellular homeostasis and gene expression. Additionally, RNF40 is subject to alternative splicing, resulting in four distinct isoforms, which may have unique regulatory functions and implications in various biological processes.
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RNF40 Antibody (1C1) References:
- RBP95, a novel leucine zipper protein, binds to the retinoblastoma protein. | Wen, H. and Ao, S. 2000. Biochem Biophys Res Commun. 275: 141-8. PMID: 10944455
- Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation. | Chin, LS., et al. 2002. J Biol Chem. 277: 35071-9. PMID: 12121982
- The role of adenovirus-mediated retinoblastoma 94 in the treatment of head and neck cancer. | Li, D., et al. 2002. Cancer Res. 62: 4637-44. PMID: 12183420
- A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. | Hwang, WW., et al. 2003. Mol Cell. 11: 261-6. PMID: 12535538
- Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. | Wood, A., et al. 2003. Mol Cell. 11: 267-74. PMID: 12535539
- Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. | Zhu, B., et al. 2005. Mol Cell. 20: 601-11. PMID: 16307923
- The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions. | Kim, J., et al. 2005. Mol Cell. 20: 759-70. PMID: 16337599
- RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk. | Najafova, Z., et al. 2021. Cell Death Differ. 28: 700-714. PMID: 32901120
- Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis. | Fu, J., et al. 2021. Oncogene. 40: 465-474. PMID: 33199825
- RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease. | Kosinsky, RL., et al. 2021. Cell Death Differ. 28: 3161-3175. PMID: 34088983
- RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo. | Liu, J., et al. 2023. Allergol Immunopathol (Madr). 51: 1-9. PMID: 37422774
- RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer. | Prokakis, E., et al. 2023. Cell Death Dis. 14: 641. PMID: 37770435
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNF40 Antibody (1C1) | sc-293333 | 100 µg/ml | $316.00 |