RNF38 Antibody (E-7): sc-515213

RNF38 Antibody (E-7) is a mouse monoclonal IgM antibody that detects RNF38 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RNF38 antibody (E-7) is available as a non-conjugated format. RNF38, also known as RING finger protein 38, is a 515 amino acid protein characterized by the presence of a RING-type zinc finger motif, which is crucial for function in the ubiquitination pathway of protein degradation. This motif consists of a conserved cysteine-rich domain capable of binding two zinc ions, a feature essential for structural integrity and functional activity. RNF38 plays a significant role in transcriptional regulation and protein degradation, processes vital for maintaining cellular homeostasis and regulating various biological pathways. Defects in RNF38 have been linked to several disorders, including acromesomelic dysplasia, arthrogryposis distal multiplex congenita type 1, and autosomal recessive ataxic cerebral palsy, as well as various malignancies. Alternative splicing of RNF38 results in the expression of two isoforms, further underscoring the complexity and significance in cellular functions.

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RNF38 Antibody (E-7) References:

1. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.  |  Lorick, KL., et al. 1999. Proc Natl Acad Sci U S A. 96: 11364-9. PMID: 10500182
2. Cloning and characterization of a novel human gene RNF38 encoding a conserved putative protein with a RING finger domain.  |  Eisenberg, I., et al. 2002. Biochem Biophys Res Commun. 294: 1169-76. PMID: 12074600
3. Functional proteomics mapping of a human signaling pathway.  |  Colland, F., et al. 2004. Genome Res. 14: 1324-32. PMID: 15231748
4. Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.  |  Penengo, L., et al. 2006. Cell. 124: 1183-95. PMID: 16499958
5. The RING finger domain: a recent example of a sequence-structure family.  |  Borden, KL. and Freemont, PS. 1996. Curr Opin Struct Biol. 6: 395-401. PMID: 8804826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RNF38 Antibody (E-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-RNF38 Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RNF38 Antibody (E-7) Specifications

Alternate Product Name: RNF38

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 86-102

Epitope Target: RNF38

Epitope Species: human

Product Reactivity/Detection: RNF38 isoforms 1 and 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for RNF38 Antibody (E-7): P: Blocking Peptide, X: TransCruz Reagent