Date published: 2026-3-17

1-800-457-3801

SCBT Portrait Logo
Seach Input

RNF26 Antibody (1-RE42): sc-134428

4.0(1)
Write a reviewAsk a question

Datasheets
  • RNF26 Antibody (1-RE42) is a mouse monoclonal IgG3 κ RNF26 antibody provided at 100 µg/ml
  • raised against recombinant RNF26 protein of human origin
  • recommended for detection of RNF26 of human origin by WB, IP and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RNF26 Antibody (1-RE42). This work is in progress.
    Crispr Promo Banner

    QUICK LINKS

    SEE ALSO...

    RNF26 Antibody (1-RE42) is a mouse monoclonal IgG3 kappa light chain antibody that detects the RNF26 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-RNF26 antibody (1-RE42) is available as a non-conjugated format. RNF26, also known as ring finger protein 26, is a 433 amino acid protein that plays a crucial role in the ubiquitination pathway, which is essential for protein degradation and cellular regulation. RNF26 contains a RING-type zinc finger motif, characterized by a conserved cysteine-rich domain capable of binding two zinc ions, which is significant for mediating protein-protein interactions and facilitating the ubiquitination process. RNF26 is ubiquitously expressed and has been found to be upregulated in various cancer cell lines, indicating potential involvement in tumorigenesis. The gene encoding RNF26 is located on human chromosome 11, a region associated with several genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome, highlighting RNF26′s importance in both normal cellular function and disease states.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    RNF26 Antibody (1-RE42) References:

    1. Hereditary angioedema. Long-term follow-up of 88 patients. Experience of the Argentine Allergy and Immunology Institute.  |  Fabiani, JE., et al. 2000. Allergol Immunopathol (Madr). 28: 267-71. PMID: 11270087
    2. Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper.  |  Katoh, M. 2001. Biochem Biophys Res Commun. 282: 1038-44. PMID: 11352657
    3. Smith-Lemli-Opitz syndrome and the DHCR7 gene.  |  Jira, PE., et al. 2003. Ann Hum Genet. 67: 269-80. PMID: 12914579
    4. The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease.  |  Schuchman, EH. 2007. J Inherit Metab Dis. 30: 654-63. PMID: 17632693
    5. Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome).  |  Coldren, CD., et al. 2009. Neurogenetics. 10: 89-95. PMID: 18855024
    6. An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome.  |  Bhuiyan, ZA., et al. 2008. Prog Biophys Mol Biol. 98: 319-27. PMID: 19027783
    7. RNF26 Promotes Pancreatic Cancer Proliferation by Enhancing RBM38 Degradation.  |  Lu, X., et al. Pancreas. 51: 1427-1433. PMID: 37099788
    8. RNF26 binds perinuclear vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress.  |  Cremer, T., et al. 2023. EMBO J. 42: e111252. PMID: 37519262
    9. RNF26 and vimentin orchestrate ER stress recovery.  |  Strzyz, P. 2023. Nat Rev Mol Cell Biol. 24: 689. PMID: 37592062
    10. RNF26-mediated ubiquitination of TRIM21 promotes bladder cancer progression.  |  Yao, D., et al. 2024. Am J Cancer Res. 14: 4082-4095. PMID: 39267687
    11. The RING finger. A novel protein sequence motif related to the zinc finger.  |  Freemont, PS. 1993. Ann N Y Acad Sci. 684: 174-92. PMID: 8317827
    12. The RING finger domain: a recent example of a sequence-structure family.  |  Borden, KL. and Freemont, PS. 1996. Curr Opin Struct Biol. 6: 395-401. PMID: 8804826

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    RNF26 Antibody (1-RE42)

    sc-134428
    100 µg/ml
    $339.00

    For Western Blot, is it recommended to use denatured or non-denatured conditions with RNF26 (1-RE42): sc-134428 antibody?

    Asked by: cjMara
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-03-27
    • y_2026, m_3, d_16, h_6CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_1
    • loc_en_US, sid_134428, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 94ms
    • QUESTIONS, PRODUCT
    Rated 4 out of 5 by from Good specificity shown by using transfectedGood specificity shown by using transfected and non-transfected 293T cells for over-expression of the human RNF26 protein via Western Blot analysis. -SCBT QC
    Date published: 2014-02-05
    • y_2026, m_3, d_16, h_6
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_1
    • loc_en_US, sid_134428, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 19ms
    • REVIEWS, PRODUCT
    RNF26 Antibody (1-RE42) is rated 4.0 out of 5 by 1.
    • y_2026, m_3, d_16, h_6
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_1
    • loc_en_US, sid_134428, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 98ms
    • REVIEWS, PRODUCT