RNF26 Inhibitors
RNF26 inhibitors predominantly target the ubiquitin-proteasome system (UPS), a cellular machinery responsible for the degradation of proteins. Through various mechanisms, these chemicals can modulate the activity or levels of RNF26. MG132, Bortezomib, Lactacystin, and Epoxomicin are proteasome inhibitors, preventing the degradation of ubiquitinated proteins. By disrupting this crucial downstream step, these compounds indirectly stabilize and can amplify the influence of RNF26 in cellular processes.
Additionally, MLN4924, PYR-41, and TAK-243 serve as inhibitors that block different stages of the ubiquitination cascade. For example, MLN4924 inhibits neddylation, a process that can indirectly influence RNF26-associated ubiquitination. PYR-41 and TAK-243, on the other hand, specifically target the E1 ubiquitin-activating enzyme, thus interrupting the initial stages of the ubiquitination process. This interruption can lead to a profound influence on RNF26's ability to tag substrates for degradation. Furthermore, Nutlin-3, PR-619, and ProTAME showcase the interconnected nature of ubiquitination by targeting various components and enzymes associated with this system. For instance, Ubistatins inhibit the interaction between ubiquitin and proteasome, Nutlin-3 affects the MDM2-p53 axis in ubiquitination, and PR-619 targets deubiquitinating enzymes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that prevents degradation of ubiquitinated proteins. Can indirectly stabilize RNF26 levels. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor designed to block proteolytic activity, potentially enhancing the effect or abundance of RNF26. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Irreversible proteasome inhibitor. By hindering proteasome activity, it may indirectly modulate RNF26 function. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
Inhibits NEDD8-activating enzyme, affecting ubiquitin-like protein neddylation. Can indirectly influence RNF26-associated processes. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
E1 ubiquitin-activating enzyme inhibitor. By interrupting the ubiquitination cascade, RNF26's activity can be influenced. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Specific and irreversible proteasome inhibitor. Indirectly affects ubiquitin-dependent degradation influencing RNF26. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
MDM2 inhibitor, influencing p53 ubiquitination. Indirectly alters the ubiquitin landscape, potentially affecting RNF26. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $75.00 $184.00 $423.00 | 1 | |
Broad-spectrum deubiquitinating enzyme (DUB) inhibitor. Can indirectly influence the ubiquitination processes associated with RNF26. | ||||||
MLN7243 | 1450833-55-2 | sc-507338 | 5 mg | $340.00 | ||
E1 ubiquitin-activating enzyme inhibitor. Its action on the UPS can indirectly affect RNF26. | ||||||