RNF213 Antibody (5C12): sc-293391

RNF213 Antibody (5C12) is a mouse monoclonal IgG2a kappa light chain antibody that detects RNF213 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). RNF213 (5C12) antibody is available as the non-conjugated form. RNF213 protein, also known as ring finger protein 213 or NET57, consists of 3,280 amino acids and features a RING-type zinc finger domain, which is crucial for its role in the ubiquitination pathway of protein degradation. This domain allows RNF213 to interact with various substrates, facilitating the tagging of proteins for degradation, a process vital for maintaining cellular homeostasis and regulating protein levels within cells. RNF213 is encoded by a gene located on human chromosome 17, a region harboring significant tumor suppressor genes such as p53 and BRCA1, both essential for DNA repair and maintaining genetic integrity. Dysfunction of RNF213 has been implicated in various diseases, including certain cancers, highlighting RNF213′s potential as a biomarker for tumorigenesis and a target for therapeutic intervention. With participation in critical cellular processes, RNF213 serves as a key player in protein regulation, making anti-RNF213 antibody (5C12) an invaluable tool for researchers studying cellular mechanisms and disease pathways.

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RNF213 Antibody (5C12) References:

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